DegronMD

Uniprot ID: O75970

Source protein: Multiple PDZ domain protein

Source gene: MPDZ

Class: DEG_APCC_DBOX_1

Location: 221:229

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7263

ASA_SCORE: 72.5889

COIL: 0.7203

CONS_SCORE: 0.4152

DSS_SCORE: 0.1767

HELIX: 0.0198

FCONS_SCORE: 0.959

RIG_SCORE: 0.7715

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R235H	TCGA-59-2349	OV	TCGA	ARGSLPQLV	DEG_APCC_DBOX_1	0.1667
p.R235H	TCGA-BR-A4J5	STAD	TCGA	ARGSLPQLV	DEG_APCC_DBOX_1	0.1667
p.R235H	DO28621	OV	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	0.1667
p.R235H	DO38185	STAD	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	0.1667
p.S236P	TCGA-DI-A1BU	UCEC	TCGA	ARGSLPQLV	DEG_APCC_DBOX_1	0.1389
p.S236P	DO42023	UCEC	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	0.1389
p.A221S	TCGA-FA-A82F	DLBC	TCGA	ARGSLPQLV	DEG_APCC_DBOX_1	0.6477
p.A221S	DO219891	DLBC	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	0.6477
p.S236F	TCGA-VQ-A925	STAD	TCGA	ARGSLPQLV	DEG_APCC_DBOX_1	0.1389
p.S236F	DO51796	STAD	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	0.1389
p.G225E	DO22253	LGG	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	0.7199
p.G218A	DO22253	LGG	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	0.25
p.A224D	DO229018	LICA	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	0.7793
p.S238Y	DO229019	LICA	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	0.0833
p.G220V	DO26419	LUSC	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	0.3056
p.I236V	DO222502	MELA	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	0.1389
p.D228Y	DO50075	UCEC	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	0.7325
p.I220L	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	ARGSLPQLV	DEG_APCC_DBOX_1	0.3056
p.I220L	SIDM00721	Small Cell Lung Carcinoma	GDSC	ARGSLPQLV	DEG_APCC_DBOX_1	0.3056
p.I220L	SIDM00785	Acute Myeloid Leukemia	GDSC	ARGSLPQLV	DEG_APCC_DBOX_1	0.3056
p.I220T	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	ARGSLPQLV	DEG_APCC_DBOX_1	0.3056
p.I220T	SIDM00736	Non-Cancerous	GDSC	ARGSLPQLV	DEG_APCC_DBOX_1	0.3056
p.I220T	ACH-000886	Lung Cancer	CCLE	ARGSLPQLV	DEG_APCC_DBOX_1	0.3056
p.I220T	ACH-002366	Non-Cancerous	CCLE	ARGSLPQLV	DEG_APCC_DBOX_1	0.3056
p.R222I	SIDM00721	Small Cell Lung Carcinoma	GDSC	ARGSLPQLV	DEG_APCC_DBOX_1	0.8102
p.R222I	ACH-002171	Lung Cancer	CCLE	ARGSLPQLV	DEG_APCC_DBOX_1	0.8102
p.R222I	NCI-H250	lung	COSMIC	ARGSLPQLV	DEG_APCC_DBOX_1	0.8102
p.D228G	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	ARGSLPQLV	DEG_APCC_DBOX_1	0.7198
p.G215D	SW900	lung	COSMIC	ARGSLPQLV	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARGSLPQLV

Degron related mutations and impact score

Drug responses associated with MPDZ mutations

All proteins holding degron of ARGSLPQLV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75970	Multiple PDZ domain protein	DEG_APCC_DBOX_1	221:229	ARGSLPQLV	APC,CDC20,FZR1	0.7263	More...