DegronMD - O75970(MPDZ)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L1951F	TCGA-21-1083	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	1960:1964	Mutation rewiring degron network	0.0833
p.R235H	TCGA-59-2349	OV	TCGA	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.1667
p.R235H	TCGA-BR-A4J5	STAD	TCGA	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.1667
p.R235H	DO28621	OV	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.1667
p.R235H	DO38185	STAD	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.1667
p.L1548I	TCGA-AG-3892	READ	TCGA	KLTIHAE	LIG_APCC_ABBAyCdc20_2	1557:1563	Mutation rewiring degron network	0.0833
p.S1958Y	TCGA-AN-A046	BRCA	TCGA	PASSS	DEG_SPOP_SBC_1	1960:1964	Mutation rewiring degron network	0.2778
p.S503L	TCGA-AN-A046	BRCA	TCGA	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.0833
p.S503L	TCGA-CA-6717	COAD	TCGA	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.0833
p.S503L	TCGA-D1-A17Q	UCEC	TCGA	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.0833
p.S503L	DO1285	BRCA	ICGC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.0833
p.S503L	DO8264	COAD	ICGC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.0833
p.S503L	DO41903	UCEC	ICGC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.0833
p.S503L	SIDM00118	Colorectal Carcinoma	GDSC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.0833
p.S503L	ACH-001081	Colon/Colorectal Cancer	CCLE	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.0833
p.S503L	HCC2998	large intestine	COSMIC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.0833
p.E492D	TCGA-B5-A1MR	UCEC	TCGA	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation altering degron motif	0.6758
p.E492D	DO41758	UCEC	ICGC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation altering degron motif	0.6758
p.E495K	TCGA-BG-A2L7	UCEC	TCGA	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.3056
p.E495K	DO42344	UCEC	ICGC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.3056
p.L501V	TCGA-CA-6718	COAD	TCGA	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.1389
p.L501V	DO7801	COAD	ICGC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.1389
p.S236P	TCGA-DI-A1BU	UCEC	TCGA	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.1389
p.S236P	DO42023	UCEC	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.1389
p.E498K	TCGA-EA-A3HU	CESC	TCGA	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.2222
p.E498K	DO6320	CESC	ICGC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.2222
p.D481Y	TCGA-EE-A183	SKCM	TCGA	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.0833
p.D481Y	DO37715	SKCM	ICGC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.0833
p.A221S	TCGA-FA-A82F	DLBC	TCGA	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation altering degron motif	0.6477
p.A221S	DO219891	DLBC	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation altering degron motif	0.6477
p.E1580K	TCGA-FR-A8YC	SKCM	TCGA	ENPDSQAVPSA	DEG_COP1_1	1563:1573	Mutation rewiring degron network	0.1389
p.L1968F	TCGA-FV-A3I0	LIHC	TCGA	PASSS	DEG_SPOP_SBC_1	1960:1964	Mutation rewiring degron network	0.2222
p.S236F	TCGA-VQ-A925	STAD	TCGA	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.1389
p.S236F	DO51796	STAD	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.1389
p.S1954Y	DO1285	BRCA	ICGC	PASSS	DEG_SPOP_SBC_1	1960:1964	Mutation rewiring degron network	0.1667
p.D1583H	DO219594	BRCA	ICGC	ENPDSQAVPSA	DEG_COP1_1	1563:1573	Mutation rewiring degron network	0.0556
p.E486K	DO7962	COAD	ICGC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.2222
p.G1971V	DO50230	LGG	ICGC	PASSS	DEG_SPOP_SBC_1	1960:1964	Mutation rewiring degron network	0.1389
p.G225E	DO22253	LGG	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation altering degron motif	0.7199
p.G218A	DO22253	LGG	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.25
p.A480E	DO228900	LICA	ICGC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.0556
p.A224D	DO229018	LICA	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation altering degron motif	0.7793
p.S238Y	DO229019	LICA	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.0833
p.G1970R	DO229050	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	1960:1964	Mutation rewiring degron network	0.1667
p.S1552T	DO228897	LICA	ICGC	KLTIHAE	LIG_APCC_ABBAyCdc20_2	1557:1563	Mutation rewiring degron network	0.1944
p.G220V	DO26419	LUSC	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.3056
p.D497N	DO222491	MELA	ICGC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.25
p.I236V	DO222502	MELA	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.1389
p.R495G	DO222837	MELA	ICGC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.3056
p.D497Y	DO49136	PACA	ICGC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.25
p.D1962H	DO227570	PACA	ICGC	PASSS	DEG_SPOP_SBC_1	1960:1964	Mutation altering degron motif	0.7688
p.P483S	DO51273	SKCM	ICGC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation blocking phosphorylation signal	0.5833
p.I1568T	DO229224	THCA	ICGC	ENPDSQAVPSA	DEG_COP1_1	1563:1573	Mutation altering degron motif	0.7078
p.R1569Q	DO219784	UCEC	ICGC	ENPDSQAVPSA	DEG_COP1_1	1563:1573	Mutation altering degron motif	0.7329
p.R1569Q	DO43971	UCEC	ICGC	ENPDSQAVPSA	DEG_COP1_1	1563:1573	Mutation altering degron motif	0.7329
p.D228Y	DO50075	UCEC	ICGC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation altering degron motif	0.7325
p.I1579F	DO42201	UCEC	ICGC	ENPDSQAVPSA	DEG_COP1_1	1563:1573	Mutation rewiring degron network	0.1667
p.R495Q	DO42713	UCEC	ICGC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.3056
p.R495Q	SC-1	haematopoietic and lymphoid tissue	COSMIC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.3056
p.T504M	SIDM02013	Colorectal Carcinoma	GDSC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.0556
p.I220L	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.3056
p.I220L	SIDM00721	Small Cell Lung Carcinoma	GDSC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.3056
p.I220L	SIDM00785	Acute Myeloid Leukemia	GDSC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.3056
p.S488R	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation blocking phosphorylation signal	0.7222
p.S488R	ACH-000309	Lung Cancer	CCLE	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation blocking phosphorylation signal	0.7222
p.S488R	SK-LU-1	lung	COSMIC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation blocking phosphorylation signal	0.7222
p.L1965V	SIDM00254	Neuroblastoma	GDSC	PASSS	DEG_SPOP_SBC_1	1960:1964	Mutation rewiring degron network	0.3056
p.I220T	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.3056
p.I220T	SIDM00736	Non-Cancerous	GDSC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.3056
p.I220T	ACH-000886	Lung Cancer	CCLE	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.3056
p.I220T	ACH-002366	Non-Cancerous	CCLE	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.3056
p.Q1568H	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	ENPDSQAVPSA	DEG_COP1_1	1563:1573	Mutation altering degron motif	0.647
p.Q1568H	ACH-000852	Lung Cancer	CCLE	ENPDSQAVPSA	DEG_COP1_1	1563:1573	Mutation altering degron motif	0.647
p.Q1568H	NCI-H1435	lung	COSMIC	ENPDSQAVPSA	DEG_COP1_1	1563:1573	Mutation altering degron motif	0.647
p.R222I	SIDM00721	Small Cell Lung Carcinoma	GDSC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation altering degron motif	0.8102
p.R222I	ACH-002171	Lung Cancer	CCLE	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation altering degron motif	0.8102
p.R222I	NCI-H250	lung	COSMIC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation altering degron motif	0.8102
p.Q1955H	ACH-002089	Lung Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	1960:1964	Mutation rewiring degron network	0.1944
p.Q1955H	201T	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	1960:1964	Mutation rewiring degron network	0.1944
p.G497V	NCI-H1838	lung	COSMIC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation rewiring degron network	0.25
p.A1963V	SNU-1040	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	1960:1964	Mutation altering degron motif	0.6936
p.D228G	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation altering degron motif	0.7198
p.P1555S	SW684	soft tissue	COSMIC	ENPDSQAVPSA	DEG_COP1_1	1563:1573	Mutation rewiring degron network	0.1111
p.P1555S	SW684	soft tissue	COSMIC	KLTIHAE	LIG_APCC_ABBAyCdc20_2	1557:1563	Mutation rewiring degron network	0.2778
p.Q1582H	NCI-H1435	lung	COSMIC	ENPDSQAVPSA	DEG_COP1_1	1563:1573	Mutation substituting flanking lysine	0.1944
p.G215D	SW900	lung	COSMIC	ARGSLPQLV	DEG_APCC_DBOX_1	221:229	Mutation rewiring degron network	0.1667
p.A1950T	NCI-H630	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	1960:1964	Mutation rewiring degron network	0.0556
p.E1955G	JiyoyeP-2003	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	1960:1964	Mutation rewiring degron network	0.1944
p.E490K	EJM	haematopoietic and lymphoid tissue	COSMIC	IKENY	DEG_APCC_KENBOX_2	490:494	Mutation altering degron motif	0.7022
p.Q1951H	201T	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	1960:1964	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MPDZ

UniProt ID: O75970

Entrez ID: 8777

Protein name: Multiple PDZ domain protein (Multi-PDZ domain protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MPDZ in