DegronMD

Uniprot ID: O75970

Source protein: Multiple PDZ domain protein

Source gene: MPDZ

Class: LIG_APCC_ABBAyCdc20_2

Location: 1557:1563

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6081

ASA_SCORE: 49.3143

COIL: 0.2647

CONS_SCORE: 0.3256

DSS_SCORE: 0.3369

HELIX: 0.0077

FCONS_SCORE: 0.9844

RIG_SCORE: 0.8085

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1548I	TCGA-AG-3892	READ	TCGA	KLTIHAE	LIG_APCC_ABBAyCdc20_2	0.0833
p.S1552T	DO228897	LICA	ICGC	KLTIHAE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P1555S	SW684	soft_tissue	COSMIC	KLTIHAE	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75970	Multiple PDZ domain protein	LIG_APCC_ABBAyCdc20_2	1557:1563	KLTIHAE	APC,CDC20,FZR1	0.6081	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons