DegronMD

Uniprot ID: O75970

Source protein: Multiple PDZ domain protein

Source gene: MPDZ

Class: DEG_APCC_KENBOX_2

Location: 490:494

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9973

ASA_SCORE: 114.76

COIL: 0.8174

CONS_SCORE: 0.2901

DSS_SCORE: 0.4181

HELIX: 0.133

FCONS_SCORE: 0.8955

RIG_SCORE: 0.7673

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S503L	TCGA-AN-A046	BRCA	TCGA	IKENY	DEG_APCC_KENBOX_2	0.0833
p.S503L	TCGA-CA-6717	COAD	TCGA	IKENY	DEG_APCC_KENBOX_2	0.0833
p.S503L	TCGA-D1-A17Q	UCEC	TCGA	IKENY	DEG_APCC_KENBOX_2	0.0833
p.S503L	DO1285	BRCA	ICGC	IKENY	DEG_APCC_KENBOX_2	0.0833
p.S503L	DO8264	COAD	ICGC	IKENY	DEG_APCC_KENBOX_2	0.0833
p.S503L	DO41903	UCEC	ICGC	IKENY	DEG_APCC_KENBOX_2	0.0833
p.S503L	SIDM00118	Colorectal Carcinoma	GDSC	IKENY	DEG_APCC_KENBOX_2	0.0833
p.S503L	ACH-001081	Colon/Colorectal Cancer	CCLE	IKENY	DEG_APCC_KENBOX_2	0.0833
p.S503L	HCC2998	large_intestine	COSMIC	IKENY	DEG_APCC_KENBOX_2	0.0833
p.E492D	TCGA-B5-A1MR	UCEC	TCGA	IKENY	DEG_APCC_KENBOX_2	0.6758
p.E492D	DO41758	UCEC	ICGC	IKENY	DEG_APCC_KENBOX_2	0.6758
p.E495K	TCGA-BG-A2L7	UCEC	TCGA	IKENY	DEG_APCC_KENBOX_2	0.3056
p.E495K	DO42344	UCEC	ICGC	IKENY	DEG_APCC_KENBOX_2	0.3056
p.L501V	TCGA-CA-6718	COAD	TCGA	IKENY	DEG_APCC_KENBOX_2	0.1389
p.L501V	DO7801	COAD	ICGC	IKENY	DEG_APCC_KENBOX_2	0.1389
p.E498K	TCGA-EA-A3HU	CESC	TCGA	IKENY	DEG_APCC_KENBOX_2	0.2222
p.E498K	DO6320	CESC	ICGC	IKENY	DEG_APCC_KENBOX_2	0.2222
p.D481Y	TCGA-EE-A183	SKCM	TCGA	IKENY	DEG_APCC_KENBOX_2	0.0833
p.D481Y	DO37715	SKCM	ICGC	IKENY	DEG_APCC_KENBOX_2	0.0833
p.E486K	DO7962	COAD	ICGC	IKENY	DEG_APCC_KENBOX_2	0.2222
p.A480E	DO228900	LICA	ICGC	IKENY	DEG_APCC_KENBOX_2	0.0556
p.D497N	DO222491	MELA	ICGC	IKENY	DEG_APCC_KENBOX_2	0.25
p.R495G	DO222837	MELA	ICGC	IKENY	DEG_APCC_KENBOX_2	0.3056
p.D497Y	DO49136	PACA	ICGC	IKENY	DEG_APCC_KENBOX_2	0.25
p.P483S	DO51273	SKCM	ICGC	IKENY	DEG_APCC_KENBOX_2	0.5833
p.R495Q	DO42713	UCEC	ICGC	IKENY	DEG_APCC_KENBOX_2	0.3056
p.R495Q	SC-1	haematopoietic_and_lymphoid_tissue	COSMIC	IKENY	DEG_APCC_KENBOX_2	0.3056
p.T504M	SIDM02013	Colorectal Carcinoma	GDSC	IKENY	DEG_APCC_KENBOX_2	0.0556
p.S488R	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	IKENY	DEG_APCC_KENBOX_2	0.7222
p.S488R	ACH-000309	Lung Cancer	CCLE	IKENY	DEG_APCC_KENBOX_2	0.7222
p.S488R	SK-LU-1	lung	COSMIC	IKENY	DEG_APCC_KENBOX_2	0.7222
p.G497V	NCI-H1838	lung	COSMIC	IKENY	DEG_APCC_KENBOX_2	0.25
p.E490K	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	IKENY	DEG_APCC_KENBOX_2	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IKENY

Degron related mutations and impact score

Drug responses associated with MPDZ mutations

All proteins holding degron of IKENY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75970	Multiple PDZ domain protein	DEG_APCC_KENBOX_2	490:494	IKENY	APC,CDC20,FZR1	0.9973	More...