DegronMD

Uniprot ID: O75970

Source protein: Multiple PDZ domain protein

Source gene: MPDZ

Class: DEG_COP1_1

Location: 1563:1573

E3 ligase: COP1

DEGRON score: 0.9471

ASA_SCORE: 84.4818

COIL: 0.8495

CONS_SCORE: 0.3175

DSS_SCORE: 0.5156

HELIX: 0.1075

FCONS_SCORE: 0.9825

RIG_SCORE: 0.6884

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1580K	TCGA-FR-A8YC	SKCM	TCGA	ENPDSQAVPSA	DEG_COP1_1	0.1389
p.D1583H	DO219594	BRCA	ICGC	ENPDSQAVPSA	DEG_COP1_1	0.0556
p.I1568T	DO229224	THCA	ICGC	ENPDSQAVPSA	DEG_COP1_1	0.7078
p.R1569Q	DO219784	UCEC	ICGC	ENPDSQAVPSA	DEG_COP1_1	0.7329
p.R1569Q	DO43971	UCEC	ICGC	ENPDSQAVPSA	DEG_COP1_1	0.7329
p.I1579F	DO42201	UCEC	ICGC	ENPDSQAVPSA	DEG_COP1_1	0.1667
p.Q1568H	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	ENPDSQAVPSA	DEG_COP1_1	0.647
p.Q1568H	ACH-000852	Lung Cancer	CCLE	ENPDSQAVPSA	DEG_COP1_1	0.647
p.Q1568H	NCI-H1435	lung	COSMIC	ENPDSQAVPSA	DEG_COP1_1	0.647
p.P1555S	SW684	soft_tissue	COSMIC	ENPDSQAVPSA	DEG_COP1_1	0.1111
p.Q1582H	NCI-H1435	lung	COSMIC	ENPDSQAVPSA	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75970	Multiple PDZ domain protein	DEG_COP1_1	1563:1573	ENPDSQAVPSA	COP1	0.9471	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons