DegronMD

Uniprot ID: P15289

Source protein: Arylsulfatase A

Source gene: ARSA

Class: DEG_APCC_DBOX_1

Location: 113:121

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6592

ASA_SCORE: 34.6333

COIL: 0.4514

CONS_SCORE: 0.646

DSS_SCORE: 0.1039

HELIX: 0.1109

FCONS_SCORE: 1.2551

RIG_SCORE: 0.8012

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V109M	TCGA-2W-A8YY	CESC	TCGA	ARGYLTGMA	DEG_APCC_DBOX_1	0.2222
p.A123T	TCGA-AJ-A3BH	UCEC	TCGA	ARGYLTGMA	DEG_APCC_DBOX_1	0.2778
p.G131V	TCGA-OR-A5KB	ACC	TCGA	ARGYLTGMA	DEG_APCC_DBOX_1	0.0556
p.E131K	DO49802	BLCA	ICGC	ARGYLTGMA	DEG_APCC_DBOX_1	0.0556
p.V107M	DO223732	CESC	ICGC	ARGYLTGMA	DEG_APCC_DBOX_1	0.1667
p.A121T	DO41638	UCEC	ICGC	ARGYLTGMA	DEG_APCC_DBOX_1	0.6028
p.G129V	ACH-001111	Lymphoma	CCLE	ARGYLTGMA	DEG_APCC_DBOX_1	0.1111
p.A114V	ACH-001649	Prostate Cancer	CCLE	ARGYLTGMA	DEG_APCC_DBOX_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15289	Arylsulfatase A	DEG_APCC_DBOX_1	113:121	ARGYLTGMA	APC,CDC20,FZR1	0.6592	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons