DegronMD

Uniprot ID: O95466

Source protein: Formin-like protein 1

Source gene: FMNL1

Class: DEG_APCC_DBOX_1

Location: 436:444

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8646

ASA_SCORE: 80.4444

COIL: 0.033

CONS_SCORE: 0.4254

DSS_SCORE: 0.5466

HELIX: 0.9672

FCONS_SCORE: 1.0404

RIG_SCORE: 0.7208

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R444L	TCGA-ER-A19C	SKCM	TCGA	ARKELETLR	DEG_APCC_DBOX_1	0.7316
p.R444L	DO47353	SKCM	ICGC	ARKELETLR	DEG_APCC_DBOX_1	0.7316
p.R453C	DO51861	BLCA	ICGC	ARKELETLR	DEG_APCC_DBOX_1	0.0833
p.S441G	DO8264	COAD	ICGC	ARKELETLR	DEG_APCC_DBOX_1	0.6993
p.E447Q	DO23678	LUAD	ICGC	ARKELETLR	DEG_APCC_DBOX_1	0.25
p.R438W	DO219784	UCEC	ICGC	ARKELETLR	DEG_APCC_DBOX_1	0.8634
p.R453H	DO42280	UCEC	ICGC	ARKELETLR	DEG_APCC_DBOX_1	0.0833
p.R453H	SNU-81	large_intestine	COSMIC	ARKELETLR	DEG_APCC_DBOX_1	0.0833
p.S434N	SIDM00315	Glioblastoma	GDSC	ARKELETLR	DEG_APCC_DBOX_1	0.2778
p.S434N	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	ARKELETLR	DEG_APCC_DBOX_1	0.2778
p.S434N	SIDM00365	Small Cell Lung Carcinoma	GDSC	ARKELETLR	DEG_APCC_DBOX_1	0.2778
p.S434N	SIDM01413	Oral Cavity Carcinoma	GDSC	ARKELETLR	DEG_APCC_DBOX_1	0.2778
p.L443Q	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	ARKELETLR	DEG_APCC_DBOX_1	0.7765
p.L443Q	ACH-000893	Lung Cancer	CCLE	ARKELETLR	DEG_APCC_DBOX_1	0.7765
p.L443Q	NCI-H1651	lung	COSMIC	ARKELETLR	DEG_APCC_DBOX_1	0.7765
p.A444E	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	ARKELETLR	DEG_APCC_DBOX_1	0.7701
p.R452H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	ARKELETLR	DEG_APCC_DBOX_1	0.1111
p.M453V	TOV-21G	ovary	COSMIC	ARKELETLR	DEG_APCC_DBOX_1	0.0833
p.R445H	22RV1	prostate	COSMIC	ARKELETLR	DEG_APCC_DBOX_1	0.3056
p.R438Q	HEC-1	endometrium	COSMIC	ARKELETLR	DEG_APCC_DBOX_1	0.7329
p.P450L	SNU-175	large_intestine	COSMIC	ARKELETLR	DEG_APCC_DBOX_1	0.6111
p.P450L	KYSE-140	oesophagus	COSMIC	ARKELETLR	DEG_APCC_DBOX_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95466	Formin-like protein 1	DEG_APCC_DBOX_1	436:444	ARKELETLR	APC,CDC20,FZR1	0.8646	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons