DegronMD - O95466(FMNL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R212K	TCGA-2W-A8YY	CESC	TCGA	IKLTPAHS	DEG_SCF_FBW7_1	204:211	Mutation rewiring degron network	0.3056
p.R212K	DO223732	CESC	ICGC	IKLTPAHS	DEG_SCF_FBW7_1	204:211	Mutation rewiring degron network	0.3056
p.K205R	TCGA-58-8391	LUSC	TCGA	IKLTPAHS	DEG_SCF_FBW7_1	204:211	Mutation altering degron motif	0.6126
p.V221I	TCGA-AJ-A8CT	UCEC	TCGA	IKLTPAHS	DEG_SCF_FBW7_1	204:211	Mutation rewiring degron network	0.0556
p.V221I	DO52399	UCEC	ICGC	IKLTPAHS	DEG_SCF_FBW7_1	204:211	Mutation rewiring degron network	0.0556
p.R219H	TCGA-B5-A5OC	UCEC	TCGA	IKLTPAHS	DEG_SCF_FBW7_1	204:211	Mutation rewiring degron network	0.1111
p.R219H	DO52405	UCEC	ICGC	IKLTPAHS	DEG_SCF_FBW7_1	204:211	Mutation rewiring degron network	0.1111
p.S195Y	TCGA-CC-A7IH	LIHC	TCGA	IKLTPAHS	DEG_SCF_FBW7_1	204:211	Mutation rewiring degron network	0.0833
p.S195Y	DO52181	LIHC	ICGC	IKLTPAHS	DEG_SCF_FBW7_1	204:211	Mutation rewiring degron network	0.0833
p.R444L	TCGA-ER-A19C	SKCM	TCGA	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation altering degron motif	0.7316
p.R444L	DO47353	SKCM	ICGC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation altering degron motif	0.7316
p.L202M	TCGA-VS-A8EL	CESC	TCGA	IKLTPAHS	DEG_SCF_FBW7_1	204:211	Mutation rewiring degron network	0.2778
p.L202M	DO51624	CESC	ICGC	IKLTPAHS	DEG_SCF_FBW7_1	204:211	Mutation rewiring degron network	0.2778
p.R453C	DO51861	BLCA	ICGC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.0833
p.R219C	DO224768	BRCA	ICGC	IKLTPAHS	DEG_SCF_FBW7_1	204:211	Mutation rewiring degron network	0.1111
p.S441G	DO8264	COAD	ICGC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation altering degron motif	0.6993
p.R200L	DO229026	LICA	ICGC	IKLTPAHS	DEG_SCF_FBW7_1	204:211	Mutation rewiring degron network	0.2222
p.E447Q	DO23678	LUAD	ICGC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.25
p.R438W	DO219784	UCEC	ICGC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation altering degron motif	0.8634
p.R219Q	DO42033	UCEC	ICGC	IKLTPAHS	DEG_SCF_FBW7_1	204:211	Mutation rewiring degron network	0.1111
p.R453H	DO42280	UCEC	ICGC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.0833
p.R453H	SNU-81	large intestine	COSMIC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.0833
p.S434N	SIDM00315	Glioblastoma	GDSC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.2778
p.S434N	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.2778
p.S434N	SIDM00365	Small Cell Lung Carcinoma	GDSC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.2778
p.S434N	SIDM01413	Oral Cavity Carcinoma	GDSC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.2778
p.L443Q	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation altering degron motif	0.7765
p.L443Q	ACH-000893	Lung Cancer	CCLE	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation altering degron motif	0.7765
p.L443Q	NCI-H1651	lung	COSMIC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation altering degron motif	0.7765
p.A444E	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation altering degron motif	0.7701
p.R452H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.1111
p.M453V	TOV-21G	ovary	COSMIC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.0833
p.R445H	22RV1	prostate	COSMIC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation rewiring degron network	0.3056
p.R438Q	HEC-1	endometrium	COSMIC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation altering degron motif	0.7329
p.P450L	SNU-175	large intestine	COSMIC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation blocking phosphorylation signal	0.6111
p.P450L	KYSE-140	oesophagus	COSMIC	ARKELETLR	DEG_APCC_DBOX_1	436:444	Mutation blocking phosphorylation signal	0.6111

Kaplan plot for FMNL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FMNL1

UniProt ID: O95466

Entrez ID: 752

Protein name: Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FMNL1 in