DegronMD

Uniprot ID: O95466

Source protein: Formin-like protein 1

Source gene: FMNL1

Class: DEG_SCF_FBW7_1

Location: 204:211

E3 ligase: FBXW7

DEGRON score: 0.9555

ASA_SCORE: 70.6125

COIL: 0.4425

CONS_SCORE: 0.3514

DSS_SCORE: 0.5033

HELIX: 0.4541

FCONS_SCORE: 0.9905

RIG_SCORE: 0.7377

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R212K	TCGA-2W-A8YY	CESC	TCGA	IKLTPAHS	DEG_SCF_FBW7_1	0.3056
p.R212K	DO223732	CESC	ICGC	IKLTPAHS	DEG_SCF_FBW7_1	0.3056
p.K205R	TCGA-58-8391	LUSC	TCGA	IKLTPAHS	DEG_SCF_FBW7_1	0.6126
p.V221I	TCGA-AJ-A8CT	UCEC	TCGA	IKLTPAHS	DEG_SCF_FBW7_1	0.0556
p.V221I	DO52399	UCEC	ICGC	IKLTPAHS	DEG_SCF_FBW7_1	0.0556
p.R219H	TCGA-B5-A5OC	UCEC	TCGA	IKLTPAHS	DEG_SCF_FBW7_1	0.1111
p.R219H	DO52405	UCEC	ICGC	IKLTPAHS	DEG_SCF_FBW7_1	0.1111
p.S195Y	TCGA-CC-A7IH	LIHC	TCGA	IKLTPAHS	DEG_SCF_FBW7_1	0.0833
p.S195Y	DO52181	LIHC	ICGC	IKLTPAHS	DEG_SCF_FBW7_1	0.0833
p.L202M	TCGA-VS-A8EL	CESC	TCGA	IKLTPAHS	DEG_SCF_FBW7_1	0.2778
p.L202M	DO51624	CESC	ICGC	IKLTPAHS	DEG_SCF_FBW7_1	0.2778
p.R219C	DO224768	BRCA	ICGC	IKLTPAHS	DEG_SCF_FBW7_1	0.1111
p.R200L	DO229026	LICA	ICGC	IKLTPAHS	DEG_SCF_FBW7_1	0.2222
p.R219Q	DO42033	UCEC	ICGC	IKLTPAHS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95466	Formin-like protein 1	DEG_SCF_FBW7_1	204:211	IKLTPAHS	FBXW7	0.9555	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons