DegronMD

Uniprot ID: Q3KP44

Source protein: Ankyrin repeat domain-containing protein 55

Source gene: ANKRD55

Class: DEG_APCC_DBOX_1

Location: 425:433

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9982

ASA_SCORE: 73.5889

COIL: 0.7818

CONS_SCORE: 0.5271

DSS_SCORE: 0.5558

HELIX: 0.1038

FCONS_SCORE: 1.0305

RIG_SCORE: 0.7013

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T434M	TCGA-32-2616	GBM	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	0.3056
p.L437V	TCGA-4Z-AA80	BLCA	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	0.2222
p.L417I	TCGA-AA-A010	COAD	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	0.1111
p.L417I	TCGA-AN-A046	BRCA	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	0.1111
p.Y416H	TCGA-AG-3892	READ	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	0.0833
p.L418F	TCGA-D3-A8GI	SKCM	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	0.1389
p.L437H	TCGA-DD-AAC8	LIHC	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	0.2222
p.P438Q	TCGA-ER-A19Q	SKCM	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	0.1944
p.P423L	TCGA-G4-6588	COAD	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	0.2778
p.L442M	TCGA-GN-A262	SKCM	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	0.0833
p.R431Q	DO229062	LICA	ICGC	ARKGLPPIR	DEG_APCC_DBOX_1	0.7329
p.S430T	DO45438	LUSC	ICGC	ARKGLPPIR	DEG_APCC_DBOX_1	0.7116
p.R426Q	DO222491	MELA	ICGC	ARKGLPPIR	DEG_APCC_DBOX_1	0.7329
p.R426Q	DO50301	SKCM	ICGC	ARKGLPPIR	DEG_APCC_DBOX_1	0.7329
p.R426Q	DO51249	SKCM	ICGC	ARKGLPPIR	DEG_APCC_DBOX_1	0.7329
p.R440K	DO37448	SKCM	ICGC	ARKGLPPIR	DEG_APCC_DBOX_1	0.1389
p.Q425H	DO42673	UCEC	ICGC	ARKGLPPIR	DEG_APCC_DBOX_1	0.7582
p.G428E	SIDM00190	Melanoma	GDSC	ARKGLPPIR	DEG_APCC_DBOX_1	0.6087
p.G428E	ACH-002097	Skin Cancer	CCLE	ARKGLPPIR	DEG_APCC_DBOX_1	0.6087
p.G428E	CP66-MEL	skin	COSMIC	ARKGLPPIR	DEG_APCC_DBOX_1	0.6087
p.A424T	LU-135	lung	COSMIC	ARKGLPPIR	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3KP44	Ankyrin repeat domain-containing protein 55	DEG_APCC_DBOX_1	425:433	ARKGLPPIR	APC,CDC20,FZR1	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons