DegronMD - Q3KP44(ANKRD55)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T434M	TCGA-32-2616	GBM	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.3056
p.L437V	TCGA-4Z-AA80	BLCA	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.2222
p.N566K	TCGA-61-2109	OV	TCGA	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation altering degron motif	0.5806
p.A568T	TCGA-A5-A1OF	UCEC	TCGA	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation altering degron motif	0.6028
p.A568T	SIDM00449	B-Lymphoblastic Leukemia	GDSC	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation altering degron motif	0.6028
p.A568T	ACH-000922	Leukemia	CCLE	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation altering degron motif	0.6028
p.A568T	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation altering degron motif	0.6028
p.L417I	TCGA-AA-A010	COAD	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.1111
p.L417I	TCGA-AN-A046	BRCA	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.1111
p.Y416H	TCGA-AG-3892	READ	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.0833
p.S577Y	TCGA-BS-A0UV	UCEC	TCGA	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.1667
p.L418F	TCGA-D3-A8GI	SKCM	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.1389
p.L437H	TCGA-DD-AAC8	LIHC	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.2222
p.R564Q	TCGA-E7-A6MD	BLCA	TCGA	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation altering degron motif	0.7329
p.P569L	TCGA-EE-A181	SKCM	TCGA	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation altering degron motif	0.6471
p.L570I	TCGA-EE-A2GT	SKCM	TCGA	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation altering degron motif	0.6063
p.P438Q	TCGA-ER-A19Q	SKCM	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.1944
p.P423L	TCGA-G4-6588	COAD	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.2778
p.L442M	TCGA-GN-A262	SKCM	TCGA	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.0833
p.N565K	TCGA-UT-A88C	MESO	TCGA	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation altering degron motif	0.5806
p.P580H	TCGA-VQ-A8E3	STAD	TCGA	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.0833
p.E561K	DO48576	BLCA	ICGC	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.2778
p.A564D	DO229031	LICA	ICGC	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation altering degron motif	0.7793
p.R431Q	DO229062	LICA	ICGC	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation altering degron motif	0.7329
p.S430T	DO45438	LUSC	ICGC	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation altering degron motif	0.7116
p.R426Q	DO222491	MELA	ICGC	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation altering degron motif	0.7329
p.R426Q	DO50301	SKCM	ICGC	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation altering degron motif	0.7329
p.R426Q	DO51249	SKCM	ICGC	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation altering degron motif	0.7329
p.S554I	DO232224	PBCA	ICGC	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.0833
p.R440K	DO37448	SKCM	ICGC	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.1389
p.P566S	DO38123	SKCM	ICGC	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation altering degron motif	0.6752
p.A557T	DO42201	UCEC	ICGC	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.1667
p.Q425H	DO42673	UCEC	ICGC	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation altering degron motif	0.7582
p.L567V	SIDM00446	Acute Myeloid Leukemia	GDSC	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation altering degron motif	0.6765
p.L567V	ACH-000113	Leukemia	CCLE	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation altering degron motif	0.6765
p.L567V	OCI-AML2	haematopoietic and lymphoid tissue	COSMIC	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation altering degron motif	0.6765
p.G428E	SIDM00190	Melanoma	GDSC	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation altering degron motif	0.6087
p.G428E	ACH-002097	Skin Cancer	CCLE	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation altering degron motif	0.6087
p.G428E	CP66-MEL	skin	COSMIC	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation altering degron motif	0.6087
p.L576V	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.1944
p.L576V	ACH-000945	Lung Cancer	CCLE	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.1944
p.L576V	NCI-H650	lung	COSMIC	TRNNLAPLP	DEG_APCC_DBOX_1	563:571	Mutation rewiring degron network	0.1944
p.A424T	LU-135	lung	COSMIC	ARKGLPPIR	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKRD55

UniProt ID: Q3KP44

Entrez ID: 79722

Protein name: Ankyrin repeat domain-containing protein 55

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKRD55 in