DegronMD

Uniprot ID: Q3KP44

Source protein: Ankyrin repeat domain-containing protein 55

Source gene: ANKRD55

Class: DEG_APCC_DBOX_1

Location: 563:571

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9736

ASA_SCORE: 65.1333

COIL: 0.8041

CONS_SCORE: 0.5477

DSS_SCORE: 0.4949

HELIX: 0.0777

FCONS_SCORE: 0.9959

RIG_SCORE: 0.7175

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N566K	TCGA-61-2109	OV	TCGA	TRNNLAPLP	DEG_APCC_DBOX_1	0.5806
p.A568T	TCGA-A5-A1OF	UCEC	TCGA	TRNNLAPLP	DEG_APCC_DBOX_1	0.6028
p.A568T	SIDM00449	B-Lymphoblastic Leukemia	GDSC	TRNNLAPLP	DEG_APCC_DBOX_1	0.6028
p.A568T	ACH-000922	Leukemia	CCLE	TRNNLAPLP	DEG_APCC_DBOX_1	0.6028
p.A568T	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	TRNNLAPLP	DEG_APCC_DBOX_1	0.6028
p.S577Y	TCGA-BS-A0UV	UCEC	TCGA	TRNNLAPLP	DEG_APCC_DBOX_1	0.1667
p.R564Q	TCGA-E7-A6MD	BLCA	TCGA	TRNNLAPLP	DEG_APCC_DBOX_1	0.7329
p.P569L	TCGA-EE-A181	SKCM	TCGA	TRNNLAPLP	DEG_APCC_DBOX_1	0.6471
p.L570I	TCGA-EE-A2GT	SKCM	TCGA	TRNNLAPLP	DEG_APCC_DBOX_1	0.6063
p.N565K	TCGA-UT-A88C	MESO	TCGA	TRNNLAPLP	DEG_APCC_DBOX_1	0.5806
p.P580H	TCGA-VQ-A8E3	STAD	TCGA	TRNNLAPLP	DEG_APCC_DBOX_1	0.0833
p.E561K	DO48576	BLCA	ICGC	TRNNLAPLP	DEG_APCC_DBOX_1	0.2778
p.A564D	DO229031	LICA	ICGC	TRNNLAPLP	DEG_APCC_DBOX_1	0.7793
p.S554I	DO232224	PBCA	ICGC	TRNNLAPLP	DEG_APCC_DBOX_1	0.0833
p.P566S	DO38123	SKCM	ICGC	TRNNLAPLP	DEG_APCC_DBOX_1	0.6752
p.A557T	DO42201	UCEC	ICGC	TRNNLAPLP	DEG_APCC_DBOX_1	0.1667
p.L567V	SIDM00446	Acute Myeloid Leukemia	GDSC	TRNNLAPLP	DEG_APCC_DBOX_1	0.6765
p.L567V	ACH-000113	Leukemia	CCLE	TRNNLAPLP	DEG_APCC_DBOX_1	0.6765
p.L567V	OCI-AML2	haematopoietic_and_lymphoid_tissue	COSMIC	TRNNLAPLP	DEG_APCC_DBOX_1	0.6765
p.L576V	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	TRNNLAPLP	DEG_APCC_DBOX_1	0.1944
p.L576V	ACH-000945	Lung Cancer	CCLE	TRNNLAPLP	DEG_APCC_DBOX_1	0.1944
p.L576V	NCI-H650	lung	COSMIC	TRNNLAPLP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3KP44	Ankyrin repeat domain-containing protein 55	DEG_APCC_DBOX_1	563:571	TRNNLAPLP	APC,CDC20,FZR1	0.9736	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons