DegronMD

Uniprot ID: Q5VV42

Source protein: Threonylcarbamoyladenosine tRNA methylthiotransferase

Source gene: CDKAL1

Class: DEG_APCC_DBOX_1

Location: 192:200

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8427

ASA_SCORE: 80.9556

COIL: 0.8066

CONS_SCORE: 0.6134

DSS_SCORE: 0.286

HELIX: 0.0464

FCONS_SCORE: 1.3047

RIG_SCORE: 0.8223

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R187M	TCGA-A5-A0G1	UCEC	TCGA	ARLDLPKIR	DEG_APCC_DBOX_1	0.1944
p.R187M	DO42472	UCEC	ICGC	ARLDLPKIR	DEG_APCC_DBOX_1	0.1944
p.S209F	TCGA-CG-5720	STAD	TCGA	ARLDLPKIR	DEG_APCC_DBOX_1	0.0833
p.S209F	TCGA-D3-A3ML	SKCM	TCGA	ARLDLPKIR	DEG_APCC_DBOX_1	0.0833
p.S209F	DO47413	SKCM	ICGC	ARLDLPKIR	DEG_APCC_DBOX_1	0.0833
p.S209F	DO38623	STAD	ICGC	ARLDLPKIR	DEG_APCC_DBOX_1	0.0833
p.R200K	TCGA-D1-A1NY	UCEC	TCGA	ARLDLPKIR	DEG_APCC_DBOX_1	0.6126
p.R200K	DO42512	UCEC	ICGC	ARLDLPKIR	DEG_APCC_DBOX_1	0.6126
p.R188Q	DO225365	BRCA	ICGC	ARLDLPKIR	DEG_APCC_DBOX_1	0.2222
p.R188Q	DO229018	LICA	ICGC	ARLDLPKIR	DEG_APCC_DBOX_1	0.2222
p.R193Q	DO218068	GACA	ICGC	ARLDLPKIR	DEG_APCC_DBOX_1	0.7329
p.R193Q	SIDM01118	Small Cell Lung Carcinoma	GDSC	ARLDLPKIR	DEG_APCC_DBOX_1	0.7329
p.R193Q	ACH-002175	Lung Cancer	CCLE	ARLDLPKIR	DEG_APCC_DBOX_1	0.7329
p.R193Q	NCI-H740	lung	COSMIC	ARLDLPKIR	DEG_APCC_DBOX_1	0.7329
p.R193P	DO48759	LIRI	ICGC	ARLDLPKIR	DEG_APCC_DBOX_1	0.7512
p.I208T	SIDM01040	Ovarian Carcinoma	GDSC	ARLDLPKIR	DEG_APCC_DBOX_1	0.1111
p.I208T	ACH-000574	Ovarian Cancer	CCLE	ARLDLPKIR	DEG_APCC_DBOX_1	0.1111
p.I208T	FU-OV-1	ovary	COSMIC	ARLDLPKIR	DEG_APCC_DBOX_1	0.1111
p.I199M	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARLDLPKIR	DEG_APCC_DBOX_1	0.6507
p.I199M	ACH-000158	Lymphoma	CCLE	ARLDLPKIR	DEG_APCC_DBOX_1	0.6507

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VV42	Threonylcarbamoyladenosine tRNA methylthiotransferase	DEG_APCC_DBOX_1	192:200	ARLDLPKIR	APC,CDC20,FZR1	0.8427	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons