DegronMD - Q5VV42(CDKAL1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R187M	TCGA-A5-A0G1	UCEC	TCGA	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.1944
p.R187M	DO42472	UCEC	ICGC	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.1944
p.S512L	TCGA-BS-A0UF	UCEC	TCGA	VYTPSIS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.0833
p.S512L	DO41488	UCEC	ICGC	VYTPSIS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.0833
p.S512L	SIDM00193	Colorectal Carcinoma	GDSC	VYTPSIS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.0833
p.S512L	SNU-81	large intestine	COSMIC	VYTPSIS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.0833
p.S209F	TCGA-CG-5720	STAD	TCGA	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.0833
p.S209F	TCGA-D3-A3ML	SKCM	TCGA	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.0833
p.S209F	DO47413	SKCM	ICGC	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.0833
p.S209F	DO38623	STAD	ICGC	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.0833
p.R200K	TCGA-D1-A1NY	UCEC	TCGA	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.6126
p.R200K	DO42512	UCEC	ICGC	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.6126
p.G489R	TCGA-DU-6407	LGG	TCGA	VYTPSIS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1111
p.G489R	DO22295	LGG	ICGC	VYTPSIS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1111
p.G509E	TCGA-EE-A2MP	SKCM	TCGA	VYTPSIS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1667
p.G509E	DO37818	SKCM	ICGC	VYTPSIS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1667
p.R188Q	DO225365	BRCA	ICGC	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.2222
p.R188Q	DO229018	LICA	ICGC	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.2222
p.S493C	DO50454	ESAD	ICGC	VYTPSIS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.2222
p.R193Q	DO218068	GACA	ICGC	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.7329
p.R193Q	SIDM01118	Small Cell Lung Carcinoma	GDSC	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.7329
p.R193Q	ACH-002175	Lung Cancer	CCLE	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.7329
p.R193Q	NCI-H740	lung	COSMIC	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.7329
p.R193P	DO48759	LIRI	ICGC	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.7512
p.Y498C	DO228138	PBCA	ICGC	VYTPSIS	DEG_SCF_FBW7_1	497:503	Mutation altering degron motif	0.5976
p.I208T	SIDM01040	Ovarian Carcinoma	GDSC	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.1111
p.I208T	ACH-000574	Ovarian Cancer	CCLE	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.1111
p.I208T	FU-OV-1	ovary	COSMIC	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.1111
p.P491R	SIDM01564	Colorectal Carcinoma	GDSC	VYTPSIS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1667
p.I199M	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.6507
p.I199M	ACH-000158	Lymphoma	CCLE	ARLDLPKIR	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.6507

Kaplan plot for CDKAL1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDKAL1

UniProt ID: Q5VV42

Entrez ID: 54901

Protein name: Threonylcarbamoyladenosine tRNA methylthiotransferase (EC 2.8.4.5) (CDK5 regulatory subunit-associated protein 1-like 1) (tRNA-t(6)A37 methylthiotransferase)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CDKAL1 in