DegronMD

Uniprot ID: Q5VV42

Source protein: Threonylcarbamoyladenosine tRNA methylthiotransferase

Source gene: CDKAL1

Class: DEG_SCF_FBW7_1

Location: 497:503

E3 ligase: FBXW7

DEGRON score: 0.991

ASA_SCORE: 70.6286

COIL: 0.7514

CONS_SCORE: 0.2513

DSS_SCORE: 0.4147

HELIX: 0.115

FCONS_SCORE: 0.7597

RIG_SCORE: 0.7692

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S512L	TCGA-BS-A0UF	UCEC	TCGA	VYTPSIS	DEG_SCF_FBW7_1	0.0833
p.S512L	DO41488	UCEC	ICGC	VYTPSIS	DEG_SCF_FBW7_1	0.0833
p.S512L	SIDM00193	Colorectal Carcinoma	GDSC	VYTPSIS	DEG_SCF_FBW7_1	0.0833
p.S512L	SNU-81	large_intestine	COSMIC	VYTPSIS	DEG_SCF_FBW7_1	0.0833
p.G489R	TCGA-DU-6407	LGG	TCGA	VYTPSIS	DEG_SCF_FBW7_1	0.1111
p.G489R	DO22295	LGG	ICGC	VYTPSIS	DEG_SCF_FBW7_1	0.1111
p.G509E	TCGA-EE-A2MP	SKCM	TCGA	VYTPSIS	DEG_SCF_FBW7_1	0.1667
p.G509E	DO37818	SKCM	ICGC	VYTPSIS	DEG_SCF_FBW7_1	0.1667
p.S493C	DO50454	ESAD	ICGC	VYTPSIS	DEG_SCF_FBW7_1	0.2222
p.Y498C	DO228138	PBCA	ICGC	VYTPSIS	DEG_SCF_FBW7_1	0.5976
p.P491R	SIDM01564	Colorectal Carcinoma	GDSC	VYTPSIS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VV42	Threonylcarbamoyladenosine tRNA methylthiotransferase	DEG_SCF_FBW7_1	497:503	VYTPSIS	FBXW7	0.991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons