DegronMD

Uniprot ID: Q93097

Source protein: Protein Wnt-2b

Source gene: WNT2B

Class: DEG_APCC_DBOX_1

Location: 37:45

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7588

ASA_SCORE: 70.9556

COIL: 0.0622

CONS_SCORE: 0.3723

DSS_SCORE: 0.0168

HELIX: 0.9356

FCONS_SCORE: 1.194

RIG_SCORE: 0.9303

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R38C	TCGA-BR-4362	STAD	TCGA	ARLGLACLL	DEG_APCC_DBOX_1	0.8301
p.R38C	TCGA-BR-8487	STAD	TCGA	ARLGLACLL	DEG_APCC_DBOX_1	0.8301
p.R38C	DO47867	STAD	ICGC	ARLGLACLL	DEG_APCC_DBOX_1	0.8301
p.R38C	DO38336	STAD	ICGC	ARLGLACLL	DEG_APCC_DBOX_1	0.8301
p.R55L	TCGA-CK-4951	COAD	TCGA	ARLGLACLL	DEG_APCC_DBOX_1	0.0556
p.R55L	DO10582	COAD	ICGC	ARLGLACLL	DEG_APCC_DBOX_1	0.0556
p.S36L	DO48386	BLCA	ICGC	ARLGLACLL	DEG_APCC_DBOX_1	0.3056
p.S36L	SIDM01619	Endometrial Carcinoma	GDSC	ARLGLACLL	DEG_APCC_DBOX_1	0.3056
p.S36L	ACH-000984	Endometrial/Uterine Cancer	CCLE	ARLGLACLL	DEG_APCC_DBOX_1	0.3056
p.R45Q	DO219029	BLCA	ICGC	ARLGLACLL	DEG_APCC_DBOX_1	0.7329
p.V35I	DO3406	BRCA	ICGC	ARLGLACLL	DEG_APCC_DBOX_1	0.2778
p.H33D	DO52717	CLLE	ICGC	ARLGLACLL	DEG_APCC_DBOX_1	0.2222
p.L40V	DO222884	COCA	ICGC	ARLGLACLL	DEG_APCC_DBOX_1	0.6765
p.G29V	DO229009	LICA	ICGC	ARLGLACLL	DEG_APCC_DBOX_1	0.1111
p.D31E	DO49127	PACA	ICGC	ARLGLACLL	DEG_APCC_DBOX_1	0.1667
p.G37A	DO36407	READ	ICGC	ARLGLACLL	DEG_APCC_DBOX_1	0.754
p.F36V	DO41020	UCEC	ICGC	ARLGLACLL	DEG_APCC_DBOX_1	0.3056
p.V35A	DO42568	UCEC	ICGC	ARLGLACLL	DEG_APCC_DBOX_1	0.2778
p.A28T	SIDM00767	Small Cell Lung Carcinoma	GDSC	ARLGLACLL	DEG_APCC_DBOX_1	0.0833
p.A28T	SIDM00176	Chondrosarcoma	GDSC	ARLGLACLL	DEG_APCC_DBOX_1	0.0833
p.A28T	SIDM01001	Breast Carcinoma	GDSC	ARLGLACLL	DEG_APCC_DBOX_1	0.0833
p.A28T	SIDM00039	Ovarian Carcinoma	GDSC	ARLGLACLL	DEG_APCC_DBOX_1	0.0833
p.A28T	SIDM01522	B-Lymphoblastic Leukemia	GDSC	ARLGLACLL	DEG_APCC_DBOX_1	0.0833
p.M40I	HCT-116	large_intestine	COSMIC	ARLGLACLL	DEG_APCC_DBOX_1	0.7618

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q93097	Protein Wnt-2b	DEG_APCC_DBOX_1	37:45	ARLGLACLL	APC,CDC20,FZR1	0.7588	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons