DegronMD

Uniprot ID: Q53GL7

Source protein: Protein mono-ADP-ribosyltransferase PARP10

Source gene: PARP10

Class: DEG_APCC_DBOX_1

Location: 89:97

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9319

ASA_SCORE: 53.5111

COIL: 0.5639

CONS_SCORE: 0.4873

DSS_SCORE: 0.6168

HELIX: 0.0254

FCONS_SCORE: 1.0684

RIG_SCORE: 0.6788

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P98H	TCGA-D3-A2JK	SKCM	TCGA	ARLLLQGLP	DEG_APCC_DBOX_1	0.3056
p.P98S	TCGA-QK-A6VB	HNSC	TCGA	ARLLLQGLP	DEG_APCC_DBOX_1	0.3056
p.G87S	DO229063	LICA	ICGC	ARLLLQGLP	DEG_APCC_DBOX_1	0.2778
p.D82Y	SIDM00959	Acute Myeloid Leukemia	GDSC	ARLLLQGLP	DEG_APCC_DBOX_1	0.1389
p.D82Y	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	ARLLLQGLP	DEG_APCC_DBOX_1	0.1389
p.R104C	ACH-001196	Sarcoma	CCLE	ARLLLQGLP	DEG_APCC_DBOX_1	0.1389
p.Q103R	ACH-002144	Lung Cancer	CCLE	ARLLLQGLP	DEG_APCC_DBOX_1	0.1667
p.Q103R	IST-SL1	lung	COSMIC	ARLLLQGLP	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53GL7	Protein mono-ADP-ribosyltransferase PARP10	DEG_APCC_DBOX_1	89:97	ARLLLQGLP	APC,CDC20,FZR1	0.9319	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons