DegronMD - Q53GL7(PARP10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V569A	TCGA-05-4384	LUAD	TCGA	LWTPDST	DEG_SCF_FBW7_1	577:583	Mutation rewiring degron network	0.1111
p.P98H	TCGA-D3-A2JK	SKCM	TCGA	ARLLLQGLP	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.3056
p.P568Q	TCGA-EM-A22J	THCA	TCGA	LWTPDST	DEG_SCF_FBW7_1	577:583	Mutation rewiring degron network	0.0833
p.P580Q	TCGA-GN-A26A	SKCM	TCGA	LWTPDST	DEG_SCF_FBW7_1	577:583	Mutation altering degron motif	0.7035
p.P580Q	DO39096	THCA	ICGC	LWTPDST	DEG_SCF_FBW7_1	577:583	Mutation altering degron motif	0.7035
p.P98S	TCGA-QK-A6VB	HNSC	TCGA	ARLLLQGLP	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.3056
p.L582R	DO227844	COCA	ICGC	LWTPDST	DEG_SCF_FBW7_1	577:583	Mutation altering degron motif	0.8428
p.A586T	DO218693	GACA	ICGC	LWTPDST	DEG_SCF_FBW7_1	577:583	Mutation rewiring degron network	0.25
p.A586T	DO233261	GACA	ICGC	LWTPDST	DEG_SCF_FBW7_1	577:583	Mutation rewiring degron network	0.25
p.A578S	DO233101	GACA	ICGC	LWTPDST	DEG_SCF_FBW7_1	577:583	Mutation altering degron motif	0.7588
p.P575S	DO11854	GBM	ICGC	LWTPDST	DEG_SCF_FBW7_1	577:583	Mutation rewiring degron network	0.2778
p.T591N	DO229025	LICA	ICGC	LWTPDST	DEG_SCF_FBW7_1	577:583	Mutation rewiring degron network	0.1111
p.H587Q	DO229027	LICA	ICGC	LWTPDST	DEG_SCF_FBW7_1	577:583	Mutation rewiring degron network	0.2222
p.G87S	DO229063	LICA	ICGC	ARLLLQGLP	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.2778
p.V581A	DO23618	LUAD	ICGC	LWTPDST	DEG_SCF_FBW7_1	577:583	Mutation altering degron motif	0.6936
p.P575H	DO27025	LUSC	ICGC	LWTPDST	DEG_SCF_FBW7_1	577:583	Mutation rewiring degron network	0.2778
p.L582F	DO228322	MALY	ICGC	LWTPDST	DEG_SCF_FBW7_1	577:583	Mutation altering degron motif	0.6981
p.P592Q	DO37861	SKCM	ICGC	LWTPDST	DEG_SCF_FBW7_1	577:583	Mutation rewiring degron network	0.0833
p.E577K	SIDM00594	Acute Myeloid Leukemia	GDSC	LWTPDST	DEG_SCF_FBW7_1	577:583	Mutation altering degron motif	0.7022
p.E577K	SIDM00650	Small Cell Lung Carcinoma	GDSC	LWTPDST	DEG_SCF_FBW7_1	577:583	Mutation altering degron motif	0.7022
p.E577K	SIDM01681	Non-Cancerous	GDSC	LWTPDST	DEG_SCF_FBW7_1	577:583	Mutation altering degron motif	0.7022
p.D82Y	SIDM00959	Acute Myeloid Leukemia	GDSC	ARLLLQGLP	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1389
p.D82Y	CMK	haematopoietic and lymphoid tissue	COSMIC	ARLLLQGLP	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1389
p.R104C	ACH-001196	Sarcoma	CCLE	ARLLLQGLP	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1389
p.Q103R	ACH-002144	Lung Cancer	CCLE	ARLLLQGLP	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1667
p.Q103R	IST-SL1	lung	COSMIC	ARLLLQGLP	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1667
p.L592M	FTC-133	thyroid	COSMIC	LWTPDST	DEG_SCF_FBW7_1	577:583	Mutation rewiring degron network	0.0833

Kaplan plot for PARP10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PARP10

UniProt ID: Q53GL7

Entrez ID: 84875

Protein name: Protein mono-ADP-ribosyltransferase PARP10 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10) (Poly [ADP-ribose] polymerase 10) (PARP-10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PARP10 in