DegronMD

Uniprot ID: Q53GL7

Source protein: Protein mono-ADP-ribosyltransferase PARP10

Source gene: PARP10

Class: DEG_SCF_FBW7_1

Location: 577:583

E3 ligase: FBXW7

DEGRON score: 0.966

ASA_SCORE: 70.1286

COIL: 0.7774

CONS_SCORE: 0.2667

DSS_SCORE: 0.6346

HELIX: 0.107

FCONS_SCORE: 0.6039

RIG_SCORE: 0.7036

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V569A	TCGA-05-4384	LUAD	TCGA	LWTPDST	DEG_SCF_FBW7_1	0.1111
p.P568Q	TCGA-EM-A22J	THCA	TCGA	LWTPDST	DEG_SCF_FBW7_1	0.0833
p.P580Q	TCGA-GN-A26A	SKCM	TCGA	LWTPDST	DEG_SCF_FBW7_1	0.7035
p.P580Q	DO39096	THCA	ICGC	LWTPDST	DEG_SCF_FBW7_1	0.7035
p.L582R	DO227844	COCA	ICGC	LWTPDST	DEG_SCF_FBW7_1	0.8428
p.A586T	DO218693	GACA	ICGC	LWTPDST	DEG_SCF_FBW7_1	0.25
p.A586T	DO233261	GACA	ICGC	LWTPDST	DEG_SCF_FBW7_1	0.25
p.A578S	DO233101	GACA	ICGC	LWTPDST	DEG_SCF_FBW7_1	0.7588
p.P575S	DO11854	GBM	ICGC	LWTPDST	DEG_SCF_FBW7_1	0.2778
p.T591N	DO229025	LICA	ICGC	LWTPDST	DEG_SCF_FBW7_1	0.1111
p.H587Q	DO229027	LICA	ICGC	LWTPDST	DEG_SCF_FBW7_1	0.2222
p.V581A	DO23618	LUAD	ICGC	LWTPDST	DEG_SCF_FBW7_1	0.6936
p.P575H	DO27025	LUSC	ICGC	LWTPDST	DEG_SCF_FBW7_1	0.2778
p.L582F	DO228322	MALY	ICGC	LWTPDST	DEG_SCF_FBW7_1	0.6981
p.P592Q	DO37861	SKCM	ICGC	LWTPDST	DEG_SCF_FBW7_1	0.0833
p.E577K	SIDM00594	Acute Myeloid Leukemia	GDSC	LWTPDST	DEG_SCF_FBW7_1	0.7022
p.E577K	SIDM00650	Small Cell Lung Carcinoma	GDSC	LWTPDST	DEG_SCF_FBW7_1	0.7022
p.E577K	SIDM01681	Non-Cancerous	GDSC	LWTPDST	DEG_SCF_FBW7_1	0.7022
p.L592M	FTC-133	thyroid	COSMIC	LWTPDST	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53GL7	Protein mono-ADP-ribosyltransferase PARP10	DEG_SCF_FBW7_1	577:583	LWTPDST	FBXW7	0.966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons