DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ARPDLERIC
Uniprot ID:
Q6SPF0
Source protein:
Sterile alpha motif domain-containing protein 1
Source gene:
SAMD1
Class:
DEG_APCC_DBOX_1
Location:
47:55
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7656
ASA_SCORE:
64.9556
COIL:
0.3788
CONS_SCORE:
0.6586
DSS_SCORE:
0.3822
HELIX:
0.61
FCONS_SCORE:
1.1359
RIG_SCORE:
0.7623
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K46N
DO233804
GACA
ICGC
ARPDLERIC
DEG_APCC_DBOX_1
0.3056
Drug responses associated with SAMD1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ARPDLERIC
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6SPF0
Sterile alpha motif domain-containing protein 1
DEG_APCC_DBOX_1
47:55
ARPDLERIC
APC,CDC20,FZR1
0.7656
More...