SAMD1
UniProt ID: Q6SPF0
Entrez ID: 90378
Protein name: Sterile alpha motif domain-containing protein 1 (SAM domain-containing protein 1) (Atherin)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor (PubMed:33980486). Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs (P...
FUNCTION: Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor (PubMed:33980486). Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs (PubMed:33980486). Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell (PubMed:16159594, PubMed:34006929). {ECO:0000269|PubMed:16159594, ECO:0000269|PubMed:33980486, ECO:0000269|PubMed:34006929}.
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GO - Biological processes (BP):
chromatin organization [GO:0006325]; foam cell differentiation [GO:0090077]; lipoprotein lipid oxidation [GO:0034439]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein homooligomerization [GO:0051260]; r...
chromatin organization [GO:0006325]; foam cell differentiation [GO:0090077]; lipoprotein lipid oxidation [GO:0034439]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein homooligomerization [GO:0051260]; regulation of DNA methylation-dependent heterochromatin assembly [GO:0090308]
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GO - Molecular function (MF):
chromatin binding [GO:0003682]; histone binding [GO:0042393]; low-density lipoprotein particle binding [GO:0030169]...
chromatin binding [GO:0003682]; histone binding [GO:0042393]; low-density lipoprotein particle binding [GO:0030169]
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GO - Cellular component (CC):
chromosome [GO:0005694]; extracellular space [GO:0005615]; nucleus [GO:0005634]...
chromosome [GO:0005694]; extracellular space [GO:0005615]; nucleus [GO:0005634]
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SAMD1
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Kaplan plot for SAMD1 in
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*NOTE: the Kaplan plots were collected from OncoLnc