DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
TRAELEKLI
Uniprot ID:
Q6SPF0
Source protein:
Sterile alpha motif domain-containing protein 1
Source gene:
SAMD1
Class:
DEG_APCC_DBOX_1
Location:
69:77
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9115
ASA_SCORE:
48.9667
COIL:
0.0281
CONS_SCORE:
0.4551
DSS_SCORE:
0.4466
HELIX:
0.9734
FCONS_SCORE:
0.9942
RIG_SCORE:
0.8112
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R68P
DO233035
GACA
ICGC
TRAELEKLI
DEG_APCC_DBOX_1
0.3056
p.K75N
DO229234
THCA
ICGC
TRAELEKLI
DEG_APCC_DBOX_1
0.5806
Drug responses associated with SAMD1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TRAELEKLI
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6SPF0
Sterile alpha motif domain-containing protein 1
DEG_APCC_DBOX_1
69:77
TRAELEKLI
APC,CDC20,FZR1
0.9115
More...