DegronMD

Uniprot ID: Q9Y4B5

Source protein: Microtubule cross-linking factor 1

Source gene: MTCL1

Class: DEG_APCC_DBOX_1

Location: 45:53

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9223

ASA_SCORE: 95.1444

COIL: 0.7327

CONS_SCORE: 0.3858

DSS_SCORE: 0.6776

HELIX: 0.2441

FCONS_SCORE: 1.0225

RIG_SCORE: 0.6699

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q63R	SIDM00789	Colorectal Carcinoma	GDSC	ARPFLKDLH	DEG_APCC_DBOX_1	0.0556
p.Q63R	HCT-15	large_intestine	COSMIC	ARPFLKDLH	DEG_APCC_DBOX_1	0.0556
p.A48T	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	ARPFLKDLH	DEG_APCC_DBOX_1	0.7139
p.A48T	HARA	lung	COSMIC	ARPFLKDLH	DEG_APCC_DBOX_1	0.7139
p.S44R	SIDM00240	Cervical Carcinoma	GDSC	ARPFLKDLH	DEG_APCC_DBOX_1	0.3056
p.S44R	OMC-1	cervix	COSMIC	ARPFLKDLH	DEG_APCC_DBOX_1	0.3056
p.R59Q	SIDM01228	Melanoma	GDSC	ARPFLKDLH	DEG_APCC_DBOX_1	0.1667
p.R59Q	SIDM00415	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARPFLKDLH	DEG_APCC_DBOX_1	0.1667
p.R59Q	SIDM01611	Endometrial Carcinoma	GDSC	ARPFLKDLH	DEG_APCC_DBOX_1	0.1667
p.R59Q	SIDM01760	Rhabdomyosarcoma	GDSC	ARPFLKDLH	DEG_APCC_DBOX_1	0.1667
p.V53G	WM-115	skin	COSMIC	ARPFLKDLH	DEG_APCC_DBOX_1	0.7532
p.R48W	22RV1	prostate	COSMIC	ARPFLKDLH	DEG_APCC_DBOX_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4B5	Microtubule cross-linking factor 1	DEG_APCC_DBOX_1	45:53	ARPFLKDLH	APC,CDC20,FZR1	0.9223	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons