DegronMD

Uniprot ID: Q9P1Y5

Source protein: Calmodulin-regulated spectrin-associated protein 3

Source gene: CAMSAP3

Class: DEG_APCC_DBOX_1

Location: 839:847

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9667

ASA_SCORE: 90.8444

COIL: 0.9174

CONS_SCORE: 0.413

DSS_SCORE: 0.6663

HELIX: 0.0396

FCONS_SCORE: 1.0316

RIG_SCORE: 0.7127

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L837M	TCGA-B0-5098	KIRC	TCGA	ARPGLIEIP	DEG_APCC_DBOX_1	0.2778
p.L837M	DO18938	KIRC	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	0.2778
p.R838C	TCGA-D1-A174	UCEC	TCGA	ARPGLIEIP	DEG_APCC_DBOX_1	0.3056
p.R838C	DO40900	UCEC	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	0.3056
p.H836Y	TCGA-FS-A4FC	SKCM	TCGA	ARPGLIEIP	DEG_APCC_DBOX_1	0.25
p.H836Y	DO37762	SKCM	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	0.25
p.D830N	TCGA-W3-AA1Q	SKCM	TCGA	ARPGLIEIP	DEG_APCC_DBOX_1	0.0833
p.D830N	DO219487	SKCM	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	0.0833
p.P835L	TCGA-WE-A8ZX	SKCM	TCGA	ARPGLIEIP	DEG_APCC_DBOX_1	0.2222
p.A829V	DO223060	ESCA	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	0.0556
p.G849C	DO233888	GACA	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	0.2778
p.T849M	DO232619	PBCA	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	0.2778
p.P847L	DO37782	SKCM	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	0.6471
p.P842S	DO38404	STAD	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	0.6752
p.P842S	DO229272	THCA	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	0.6752
p.H829Q	DO229218	THCA	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	0.0556
p.V847M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ARPGLIEIP	DEG_APCC_DBOX_1	0.7208
p.V847M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	ARPGLIEIP	DEG_APCC_DBOX_1	0.7208
p.V847M	ACH-000995	Leukemia	CCLE	ARPGLIEIP	DEG_APCC_DBOX_1	0.7208
p.R850C	SIDM00251	Gastric Carcinoma	GDSC	ARPGLIEIP	DEG_APCC_DBOX_1	0.25
p.H829N	SIDM01629	Melanoma	GDSC	ARPGLIEIP	DEG_APCC_DBOX_1	0.0556
p.H829N	ACH-000404	Skin Cancer	CCLE	ARPGLIEIP	DEG_APCC_DBOX_1	0.0556
p.R838H	SIDM00153	T-Lymphoblastic Leukemia	GDSC	ARPGLIEIP	DEG_APCC_DBOX_1	0.3056
p.R838H	ACH-000964	Leukemia	CCLE	ARPGLIEIP	DEG_APCC_DBOX_1	0.3056
p.A856T	ACH-000980	Lung Cancer	CCLE	ARPGLIEIP	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P1Y5	Calmodulin-regulated spectrin-associated protein 3	DEG_APCC_DBOX_1	839:847	ARPGLIEIP	APC,CDC20,FZR1	0.9667	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARPGLIEIP

Degron related mutations and impact score

Drug responses associated with CAMSAP3 mutations

All proteins holding degron of ARPGLIEIP