DegronMD - Q9P1Y5(CAMSAP3)

FUNCTION: Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:27802168, PubMed:26715742). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1115H	TCGA-A6-2686	COAD	TCGA	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation rewiring degron network	0.1111
p.R1115H	TCGA-US-A77E	PAAD	TCGA	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation rewiring degron network	0.1111
p.R1115H	ACH-001134	Lymphoma	CCLE	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation rewiring degron network	0.1111
p.R1110H	TCGA-AP-A1E0	UCEC	TCGA	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation rewiring degron network	0.25
p.R1110H	DO43154	UCEC	ICGC	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation rewiring degron network	0.25
p.R1110H	ACH-000954	Endometrial/Uterine Cancer	CCLE	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation rewiring degron network	0.25
p.E1116K	TCGA-AZ-4315	COAD	TCGA	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation rewiring degron network	0.0833
p.L837M	TCGA-B0-5098	KIRC	TCGA	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation rewiring degron network	0.2778
p.L837M	DO18938	KIRC	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation rewiring degron network	0.2778
p.R1117W	TCGA-BS-A0UV	UCEC	TCGA	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation rewiring degron network	0.0556
p.R838C	TCGA-D1-A174	UCEC	TCGA	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation rewiring degron network	0.3056
p.R838C	DO40900	UCEC	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation rewiring degron network	0.3056
p.G1091V	TCGA-ER-A19H	SKCM	TCGA	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation rewiring degron network	0.1111
p.G1091V	DO47299	SKCM	ICGC	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation rewiring degron network	0.1111
p.R1110C	TCGA-FI-A2D0	UCEC	TCGA	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation rewiring degron network	0.25
p.H836Y	TCGA-FS-A4FC	SKCM	TCGA	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation rewiring degron network	0.25
p.H836Y	DO37762	SKCM	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation rewiring degron network	0.25
p.R1094K	TCGA-FW-A3R5	SKCM	TCGA	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation rewiring degron network	0.1944
p.R1094K	DO37406	SKCM	ICGC	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation rewiring degron network	0.1944
p.R1117Q	TCGA-UD-AAC4	MESO	TCGA	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation rewiring degron network	0.0556
p.D830N	TCGA-W3-AA1Q	SKCM	TCGA	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation rewiring degron network	0.0833
p.D830N	DO219487	SKCM	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation rewiring degron network	0.0833
p.P835L	TCGA-WE-A8ZX	SKCM	TCGA	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation rewiring degron network	0.2222
p.E1089K	DO8842	COAD	ICGC	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation rewiring degron network	0.0556
p.D749N	DO223015	ESCA	ICGC	PPAAWVIPG	DEG_SIAH_1	739:747	Mutation rewiring degron network	0.2778
p.A829V	DO223060	ESCA	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation rewiring degron network	0.0556
p.P1095H	DO233205	GACA	ICGC	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation rewiring degron network	0.2222
p.G849C	DO233888	GACA	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation rewiring degron network	0.2778
p.E1106D	DO229022	LICA	ICGC	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation altering degron motif	0.5647
p.A1099S	DO229009	LICA	ICGC	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation altering degron motif	0.7588
p.P1101T	DO24566	LUAD	ICGC	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation altering degron motif	0.5919
p.T849M	DO232619	PBCA	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation rewiring degron network	0.2778
p.A729V	DO219878	SKCA	ICGC	PPAAWVIPG	DEG_SIAH_1	739:747	Mutation rewiring degron network	0.0556
p.P730S	DO229456	SKCA	ICGC	PPAAWVIPG	DEG_SIAH_1	739:747	Mutation rewiring degron network	0.0833
p.P847L	DO37782	SKCM	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation altering degron motif	0.6471
p.P842S	DO38404	STAD	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation altering degron motif	0.6752
p.P842S	DO229272	THCA	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation altering degron motif	0.6752
p.H829Q	DO229218	THCA	ICGC	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation rewiring degron network	0.0556
p.R1090W	DO42793	UCEC	ICGC	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation rewiring degron network	0.0833
p.V847M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation altering degron motif	0.7208
p.V847M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation altering degron motif	0.7208
p.V847M	ACH-000995	Leukemia	CCLE	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation altering degron motif	0.7208
p.R850C	SIDM00251	Gastric Carcinoma	GDSC	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation rewiring degron network	0.25
p.H829N	SIDM01629	Melanoma	GDSC	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation rewiring degron network	0.0556
p.H829N	ACH-000404	Skin Cancer	CCLE	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation rewiring degron network	0.0556
p.R838H	SIDM00153	T-Lymphoblastic Leukemia	GDSC	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation rewiring degron network	0.3056
p.R838H	ACH-000964	Leukemia	CCLE	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation rewiring degron network	0.3056
p.A856T	ACH-000980	Lung Cancer	CCLE	ARPGLIEIP	DEG_APCC_DBOX_1	839:847	Mutation rewiring degron network	0.0833
p.A1102V	SNU-1040	large intestine	COSMIC	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation altering degron motif	0.5825
p.G1095S	A2780	ovary	COSMIC	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation rewiring degron network	0.2222
p.Y1107S	647-V	urinary tract	COSMIC	SSPASVPEY	DEG_COP1_1	1099:1107	Mutation altering degron motif	0.712

Kaplan plot for CAMSAP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CAMSAP3

UniProt ID: Q9P1Y5

Entrez ID: 57662

Protein name: Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CAMSAP3 in