DegronMD

Uniprot ID: Q9P1Y5

Source protein: Calmodulin-regulated spectrin-associated protein 3

Source gene: CAMSAP3

Class: DEG_COP1_1

Location: 1099:1107

E3 ligase: COP1

DEGRON score: 0.9901

ASA_SCORE: 84.9778

COIL: 0.9167

CONS_SCORE: 0.5039

DSS_SCORE: 0.5401

HELIX: 0.0393

FCONS_SCORE: 0.9251

RIG_SCORE: 0.621

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1115H	TCGA-A6-2686	COAD	TCGA	SSPASVPEY	DEG_COP1_1	0.1111
p.R1115H	TCGA-US-A77E	PAAD	TCGA	SSPASVPEY	DEG_COP1_1	0.1111
p.R1115H	ACH-001134	Lymphoma	CCLE	SSPASVPEY	DEG_COP1_1	0.1111
p.R1110H	TCGA-AP-A1E0	UCEC	TCGA	SSPASVPEY	DEG_COP1_1	0.25
p.R1110H	DO43154	UCEC	ICGC	SSPASVPEY	DEG_COP1_1	0.25
p.R1110H	ACH-000954	Endometrial/Uterine Cancer	CCLE	SSPASVPEY	DEG_COP1_1	0.25
p.E1116K	TCGA-AZ-4315	COAD	TCGA	SSPASVPEY	DEG_COP1_1	0.0833
p.R1117W	TCGA-BS-A0UV	UCEC	TCGA	SSPASVPEY	DEG_COP1_1	0.0556
p.G1091V	TCGA-ER-A19H	SKCM	TCGA	SSPASVPEY	DEG_COP1_1	0.1111
p.G1091V	DO47299	SKCM	ICGC	SSPASVPEY	DEG_COP1_1	0.1111
p.R1110C	TCGA-FI-A2D0	UCEC	TCGA	SSPASVPEY	DEG_COP1_1	0.25
p.R1094K	TCGA-FW-A3R5	SKCM	TCGA	SSPASVPEY	DEG_COP1_1	0.1944
p.R1094K	DO37406	SKCM	ICGC	SSPASVPEY	DEG_COP1_1	0.1944
p.R1117Q	TCGA-UD-AAC4	MESO	TCGA	SSPASVPEY	DEG_COP1_1	0.0556
p.E1089K	DO8842	COAD	ICGC	SSPASVPEY	DEG_COP1_1	0.0556
p.P1095H	DO233205	GACA	ICGC	SSPASVPEY	DEG_COP1_1	0.2222
p.E1106D	DO229022	LICA	ICGC	SSPASVPEY	DEG_COP1_1	0.5647
p.A1099S	DO229009	LICA	ICGC	SSPASVPEY	DEG_COP1_1	0.7588
p.P1101T	DO24566	LUAD	ICGC	SSPASVPEY	DEG_COP1_1	0.5919
p.R1090W	DO42793	UCEC	ICGC	SSPASVPEY	DEG_COP1_1	0.0833
p.A1102V	SNU-1040	large_intestine	COSMIC	SSPASVPEY	DEG_COP1_1	0.5825
p.G1095S	A2780	ovary	COSMIC	SSPASVPEY	DEG_COP1_1	0.2222
p.Y1107S	647-V	urinary_tract	COSMIC	SSPASVPEY	DEG_COP1_1	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P1Y5	Calmodulin-regulated spectrin-associated protein 3	DEG_COP1_1	1099:1107	SSPASVPEY	COP1	0.9901	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons