DegronMD

Uniprot ID: P06850

Source protein: Corticoliberin

Source gene: CRH

Class: DEG_APCC_DBOX_1

Location: 61:69

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6373

ASA_SCORE: 61.7889

COIL: 0.5957

CONS_SCORE: 0.6989

DSS_SCORE: 0.5655

HELIX: 0.1173

FCONS_SCORE: 1.1043

RIG_SCORE: 0.7508

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E71D	DO232224	PBCA	ICGC	ARPVLLRMG	DEG_APCC_DBOX_1	0.2778
p.E54Q	DO43610	UCEC	ICGC	ARPVLLRMG	DEG_APCC_DBOX_1	0.1389
p.R67H	ACH-001518	Endometrial/Uterine Cancer	CCLE	ARPVLLRMG	DEG_APCC_DBOX_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P06850	Corticoliberin	DEG_APCC_DBOX_1	61:69	ARPVLLRMG	APC,CDC20,FZR1	0.6373	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons