DegronMD

Uniprot ID: Q96B36

Source protein: Proline-rich AKT1 substrate 1

Source gene: AKT1S1

Class: DEG_APCC_DBOX_1

Location: 58:66

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.574

ASA_SCORE: 59.8444

COIL: 0.2448

CONS_SCORE: 0.5456

DSS_SCORE: 0.3941

HELIX: 0.7432

FCONS_SCORE: 1.0938

RIG_SCORE: 0.7826

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P55L	DO804	BLCA	ICGC	ARRCLHDIA	DEG_APCC_DBOX_1	0.25
p.A75T	DO233882	GACA	ICGC	ARRCLHDIA	DEG_APCC_DBOX_1	0.0833
p.G62C	DO230993	LUSC	ICGC	ARRCLHDIA	DEG_APCC_DBOX_1	0.76
p.P61S	DO220885	MELA	ICGC	ARRCLHDIA	DEG_APCC_DBOX_1	0.6752
p.V49L	DO229127	NKTL	ICGC	ARRCLHDIA	DEG_APCC_DBOX_1	0.0833
p.C64S	DO229232	THCA	ICGC	ARRCLHDIA	DEG_APCC_DBOX_1	0.7541
p.A58V	ACH-000051	Sarcoma	CCLE	ARRCLHDIA	DEG_APCC_DBOX_1	0.5825
p.A58V	ACH-000758	Gastric Cancer	CCLE	ARRCLHDIA	DEG_APCC_DBOX_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96B36	Proline-rich AKT1 substrate 1	DEG_APCC_DBOX_1	58:66	ARRCLHDIA	APC,CDC20,FZR1	0.574	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons