DegronMD - Q96B36(AKT1S1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E134D	TCGA-AX-A2HC	UCEC	TCGA	LPPFCE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1667
p.E134D	DO41572	UCEC	ICGC	LPPFCE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1667
p.D144G	TCGA-D1-A2G0	UCEC	TCGA	LPPFCE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.7198
p.D144G	DO43049	UCEC	ICGC	LPPFCE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.7198
p.P55L	DO804	BLCA	ICGC	ARRCLHDIA	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.25
p.A155T	DO228029	EOPC	ICGC	LPPFCE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.0556
p.A75T	DO233882	GACA	ICGC	ARRCLHDIA	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.0833
p.G62C	DO230993	LUSC	ICGC	ARRCLHDIA	DEG_APCC_DBOX_1	58:66	Mutation altering degron motif	0.76
p.P61S	DO220885	MELA	ICGC	ARRCLHDIA	DEG_APCC_DBOX_1	58:66	Mutation altering degron motif	0.6752
p.V49L	DO229127	NKTL	ICGC	ARRCLHDIA	DEG_APCC_DBOX_1	58:66	Mutation rewiring degron network	0.0833
p.C64S	DO229232	THCA	ICGC	ARRCLHDIA	DEG_APCC_DBOX_1	58:66	Mutation altering degron motif	0.7541
p.G137R	SIDM00557	Neuroblastoma	GDSC	LPPFCE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.25
p.G137R	SIDM00993	Plasma Cell Myeloma	GDSC	LPPFCE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.25
p.G137R	SIDM00304	Ovarian Carcinoma	GDSC	LPPFCE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.25
p.G137R	SIDM00553	Acute Myeloid Leukemia	GDSC	LPPFCE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.25
p.G137R	SIDM00282	Colorectal Carcinoma	GDSC	LPPFCE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.25
p.G137R	SIDM00233	T-Lymphoblastic Leukemia	GDSC	LPPFCE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.25
p.G137R	SIDM01439	Hepatocellular Carcinoma	GDSC	LPPFCE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.25
p.E134G	SIDM01023	Acute Myeloid Leukemia	GDSC	LPPFCE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1667
p.E134G	MONO-MAC-6	haematopoietic and lymphoid tissue	COSMIC	LPPFCE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1667
p.A58V	ACH-000051	Sarcoma	CCLE	ARRCLHDIA	DEG_APCC_DBOX_1	58:66	Mutation altering degron motif	0.5825
p.A58V	ACH-000758	Gastric Cancer	CCLE	ARRCLHDIA	DEG_APCC_DBOX_1	58:66	Mutation altering degron motif	0.5825

Kaplan plot for AKT1S1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AKT1S1

UniProt ID: Q96B36

Entrez ID: 84335

Protein name: Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AKT1S1 in