DegronMD

Uniprot ID: Q96B36

Source protein: Proline-rich AKT1 substrate 1

Source gene: AKT1S1

Class: LIG_APCC_ABBA_1

Location: 140:145

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9814

ASA_SCORE: 73.7667

COIL: 0.9217

CONS_SCORE: 0.504

DSS_SCORE: 0.7772

HELIX: 0.0433

FCONS_SCORE: 1.0201

RIG_SCORE: 0.7174

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E134D	TCGA-AX-A2HC	UCEC	TCGA	LPPFCE	LIG_APCC_ABBA_1	0.1667
p.E134D	DO41572	UCEC	ICGC	LPPFCE	LIG_APCC_ABBA_1	0.1667
p.D144G	TCGA-D1-A2G0	UCEC	TCGA	LPPFCE	LIG_APCC_ABBA_1	0.7198
p.D144G	DO43049	UCEC	ICGC	LPPFCE	LIG_APCC_ABBA_1	0.7198
p.A155T	DO228029	EOPC	ICGC	LPPFCE	LIG_APCC_ABBA_1	0.0556
p.G137R	SIDM00557	Neuroblastoma	GDSC	LPPFCE	LIG_APCC_ABBA_1	0.25
p.G137R	SIDM00993	Plasma Cell Myeloma	GDSC	LPPFCE	LIG_APCC_ABBA_1	0.25
p.G137R	SIDM00304	Ovarian Carcinoma	GDSC	LPPFCE	LIG_APCC_ABBA_1	0.25
p.G137R	SIDM00553	Acute Myeloid Leukemia	GDSC	LPPFCE	LIG_APCC_ABBA_1	0.25
p.G137R	SIDM00282	Colorectal Carcinoma	GDSC	LPPFCE	LIG_APCC_ABBA_1	0.25
p.G137R	SIDM00233	T-Lymphoblastic Leukemia	GDSC	LPPFCE	LIG_APCC_ABBA_1	0.25
p.G137R	SIDM01439	Hepatocellular Carcinoma	GDSC	LPPFCE	LIG_APCC_ABBA_1	0.25
p.E134G	SIDM01023	Acute Myeloid Leukemia	GDSC	LPPFCE	LIG_APCC_ABBA_1	0.1667
p.E134G	MONO-MAC-6	haematopoietic_and_lymphoid_tissue	COSMIC	LPPFCE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96B36	Proline-rich AKT1 substrate 1	LIG_APCC_ABBA_1	140:145	LPPFCE	APC,CDC20,FZR1	0.9814	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons