DegronMD

Uniprot ID: Q96AQ8

Source protein: Mitochondrial calcium uniporter regulator 1

Source gene: MCUR1

Class: DEG_APCC_DBOX_1

Location: 38:46

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.546

ASA_SCORE: 73.0444

COIL: 0.6197

CONS_SCORE: 0.6913

DSS_SCORE: 0.4039

HELIX: 0.2526

FCONS_SCORE: 1.0379

RIG_SCORE: 0.7641

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P31R	SIDM00773	Non-Cancerous	GDSC	ARRCLSALS	DEG_APCC_DBOX_1	0.1389
p.P31R	ACH-000691	Breast Cancer	CCLE	ARRCLSALS	DEG_APCC_DBOX_1	0.1389
p.G32A	SIDM01259	B-Lymphoblastic Leukemia	GDSC	ARRCLSALS	DEG_APCC_DBOX_1	0.1667
p.G32A	ACH-001669	Leukemia	CCLE	ARRCLSALS	DEG_APCC_DBOX_1	0.1667
p.R55G	SIDM00271	Gastric Carcinoma	GDSC	ARRCLSALS	DEG_APCC_DBOX_1	0.0833
p.R55G	ACH-000351	Gastric Cancer	CCLE	ARRCLSALS	DEG_APCC_DBOX_1	0.0833
p.A38T	ACH-000870	Lung Cancer	CCLE	ARRCLSALS	DEG_APCC_DBOX_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96AQ8	Mitochondrial calcium uniporter regulator 1	DEG_APCC_DBOX_1	38:46	ARRCLSALS	APC,CDC20,FZR1	0.546	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons