DegronMD

Uniprot ID: Q5TZA2

Source protein: Rootletin

Source gene: CROCC

Class: DEG_APCC_DBOX_1

Location: 1278:1286

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5878

ASA_SCORE: 110.6444

COIL: 0.0079

CONS_SCORE: 0.7612

DSS_SCORE: 0.4022

HELIX: 0.9924

FCONS_SCORE: 1.1561

RIG_SCORE: 0.7835

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1280W	TCGA-EO-A22R	UCEC	TCGA	ARRELQELR	DEG_APCC_DBOX_1	0.7523
p.R1280W	DO42713	UCEC	ICGC	ARRELQELR	DEG_APCC_DBOX_1	0.7523
p.R1280W	ACH-000722	Colon/Colorectal Cancer	CCLE	ARRELQELR	DEG_APCC_DBOX_1	0.7523
p.R1279W	DO222817	BTCA	ICGC	ARRELQELR	DEG_APCC_DBOX_1	0.8634
p.R1275W	DO233693	GACA	ICGC	ARRELQELR	DEG_APCC_DBOX_1	0.25
p.R1275W	ACH-000984	Endometrial/Uterine Cancer	CCLE	ARRELQELR	DEG_APCC_DBOX_1	0.25
p.E1295G	DO229268	THCA	ICGC	ARRELQELR	DEG_APCC_DBOX_1	0.0833
p.R1280Q	ACH-001310	Non-Cancerous	CCLE	ARRELQELR	DEG_APCC_DBOX_1	0.6218

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TZA2	Rootletin	DEG_APCC_DBOX_1	1278:1286	ARRELQELR	APC,CDC20,FZR1	0.5878	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons