DegronMD - Q5TZA2(CROCC)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1261T	TCGA-AD-6889	COAD	TCGA	LRTGLQEVE	DEG_APCC_DBOX_1	1264:1272	Mutation rewiring degron network	0.25
p.A1261T	DO8463	COAD	ICGC	LRTGLQEVE	DEG_APCC_DBOX_1	1264:1272	Mutation rewiring degron network	0.25
p.T1266I	TCGA-AD-6889	COAD	TCGA	LRTGLQEVE	DEG_APCC_DBOX_1	1264:1272	Mutation altering degron motif	0.5966
p.T1266I	DO8463	COAD	ICGC	LRTGLQEVE	DEG_APCC_DBOX_1	1264:1272	Mutation altering degron motif	0.5966
p.R1265Q	TCGA-AJ-A3EL	UCEC	TCGA	LRTGLQEVE	DEG_APCC_DBOX_1	1264:1272	Mutation altering degron motif	0.7329
p.R1265Q	TCGA-AP-A1E0	UCEC	TCGA	LRTGLQEVE	DEG_APCC_DBOX_1	1264:1272	Mutation altering degron motif	0.7329
p.R1265Q	DO222421	BTCA	ICGC	LRTGLQEVE	DEG_APCC_DBOX_1	1264:1272	Mutation altering degron motif	0.7329
p.R1265Q	DO43154	UCEC	ICGC	LRTGLQEVE	DEG_APCC_DBOX_1	1264:1272	Mutation altering degron motif	0.7329
p.R1265Q	DO41542	UCEC	ICGC	LRTGLQEVE	DEG_APCC_DBOX_1	1264:1272	Mutation altering degron motif	0.7329
p.E1260K	TCGA-BH-A0B6	BRCA	TCGA	LRTGLQEVE	DEG_APCC_DBOX_1	1264:1272	Mutation rewiring degron network	0.2222
p.E1260K	DO2641	BRCA	ICGC	LRTGLQEVE	DEG_APCC_DBOX_1	1264:1272	Mutation rewiring degron network	0.2222
p.R1280W	TCGA-EO-A22R	UCEC	TCGA	ARRELQELR	DEG_APCC_DBOX_1	1278:1286	Mutation altering degron motif	0.7523
p.R1280W	DO42713	UCEC	ICGC	ARRELQELR	DEG_APCC_DBOX_1	1278:1286	Mutation altering degron motif	0.7523
p.R1280W	ACH-000722	Colon/Colorectal Cancer	CCLE	ARRELQELR	DEG_APCC_DBOX_1	1278:1286	Mutation altering degron motif	0.7523
p.R1279W	DO222817	BTCA	ICGC	ARRELQELR	DEG_APCC_DBOX_1	1278:1286	Mutation altering degron motif	0.8634
p.R1275W	DO233693	GACA	ICGC	LRTGLQEVE	DEG_APCC_DBOX_1	1264:1272	Mutation rewiring degron network	0.25
p.R1275W	DO233693	GACA	ICGC	ARRELQELR	DEG_APCC_DBOX_1	1278:1286	Mutation rewiring degron network	0.25
p.R1275W	ACH-000984	Endometrial/Uterine Cancer	CCLE	LRTGLQEVE	DEG_APCC_DBOX_1	1264:1272	Mutation rewiring degron network	0.25
p.R1275W	ACH-000984	Endometrial/Uterine Cancer	CCLE	ARRELQELR	DEG_APCC_DBOX_1	1278:1286	Mutation rewiring degron network	0.25
p.G1258D	DO50416	PRAD	ICGC	LRTGLQEVE	DEG_APCC_DBOX_1	1264:1272	Mutation rewiring degron network	0.1667
p.E1295G	DO229268	THCA	ICGC	ARRELQELR	DEG_APCC_DBOX_1	1278:1286	Mutation rewiring degron network	0.0833
p.G1258S	ACH-000850	Non-Cancerous	CCLE	LRTGLQEVE	DEG_APCC_DBOX_1	1264:1272	Mutation rewiring degron network	0.1667
p.R1280Q	ACH-001310	Non-Cancerous	CCLE	ARRELQELR	DEG_APCC_DBOX_1	1278:1286	Mutation altering degron motif	0.6218

Kaplan plot for CROCC in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CROCC

UniProt ID: Q5TZA2

Entrez ID: 9696

Protein name: Rootletin (Ciliary rootlet coiled-coil protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CROCC in