DegronMD

Uniprot ID: Q5TZA2

Source protein: Rootletin

Source gene: CROCC

Class: DEG_APCC_DBOX_1

Location: 1264:1272

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.566

ASA_SCORE: 92.3

COIL: 0.016

CONS_SCORE: 0.73

DSS_SCORE: 0.4397

HELIX: 0.9844

FCONS_SCORE: 1.0834

RIG_SCORE: 0.7404

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1261T	TCGA-AD-6889	COAD	TCGA	LRTGLQEVE	DEG_APCC_DBOX_1	0.25
p.A1261T	DO8463	COAD	ICGC	LRTGLQEVE	DEG_APCC_DBOX_1	0.25
p.T1266I	TCGA-AD-6889	COAD	TCGA	LRTGLQEVE	DEG_APCC_DBOX_1	0.5966
p.T1266I	DO8463	COAD	ICGC	LRTGLQEVE	DEG_APCC_DBOX_1	0.5966
p.R1265Q	TCGA-AJ-A3EL	UCEC	TCGA	LRTGLQEVE	DEG_APCC_DBOX_1	0.7329
p.R1265Q	TCGA-AP-A1E0	UCEC	TCGA	LRTGLQEVE	DEG_APCC_DBOX_1	0.7329
p.R1265Q	DO222421	BTCA	ICGC	LRTGLQEVE	DEG_APCC_DBOX_1	0.7329
p.R1265Q	DO43154	UCEC	ICGC	LRTGLQEVE	DEG_APCC_DBOX_1	0.7329
p.R1265Q	DO41542	UCEC	ICGC	LRTGLQEVE	DEG_APCC_DBOX_1	0.7329
p.E1260K	TCGA-BH-A0B6	BRCA	TCGA	LRTGLQEVE	DEG_APCC_DBOX_1	0.2222
p.E1260K	DO2641	BRCA	ICGC	LRTGLQEVE	DEG_APCC_DBOX_1	0.2222
p.R1275W	DO233693	GACA	ICGC	LRTGLQEVE	DEG_APCC_DBOX_1	0.25
p.R1275W	ACH-000984	Endometrial/Uterine Cancer	CCLE	LRTGLQEVE	DEG_APCC_DBOX_1	0.25
p.G1258D	DO50416	PRAD	ICGC	LRTGLQEVE	DEG_APCC_DBOX_1	0.1667
p.G1258S	ACH-000850	Non-Cancerous	CCLE	LRTGLQEVE	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TZA2	Rootletin	DEG_APCC_DBOX_1	1264:1272	LRTGLQEVE	APC,CDC20,FZR1	0.566	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons