DegronMD

Uniprot ID: Q8NE71

Source protein: ATP-binding cassette sub-family F member 1

Source gene: ABCF1

Class: DEG_APCC_DBOX_1

Location: 431:439

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7889

ASA_SCORE: 47.8556

COIL: 0.279

CONS_SCORE: 0.611

DSS_SCORE: 0.3421

HELIX: 0.7183

FCONS_SCORE: 1.3223

RIG_SCORE: 0.7889

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A425T	TCGA-13-0888	OV	TCGA	ARRILAGLG	DEG_APCC_DBOX_1	0.1667
p.A425T	DO30420	OV	ICGC	ARRILAGLG	DEG_APCC_DBOX_1	0.1667
p.A424V	DO222427	BTCA	ICGC	ARRILAGLG	DEG_APCC_DBOX_1	0.1389
p.A421S	DO227906	COCA	ICGC	ARRILAGLG	DEG_APCC_DBOX_1	0.0556
p.R433Q	DO233254	GACA	ICGC	ARRILAGLG	DEG_APCC_DBOX_1	0.6218
p.K430N	DO233747	GACA	ICGC	ARRILAGLG	DEG_APCC_DBOX_1	0.75
p.R433W	SIDM01619	Endometrial Carcinoma	GDSC	ARRILAGLG	DEG_APCC_DBOX_1	0.7523
p.R433W	ACH-000984	Endometrial/Uterine Cancer	CCLE	ARRILAGLG	DEG_APCC_DBOX_1	0.7523
p.D445N	COLO-792	skin	COSMIC	ARRILAGLG	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NE71	ATP-binding cassette sub-family F member 1	DEG_APCC_DBOX_1	431:439	ARRILAGLG	APC,CDC20,FZR1	0.7889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons