DegronMD - Q8NE71(ABCF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A425T	TCGA-13-0888	OV	TCGA	ARRILAGLG	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.1667
p.A425T	DO30420	OV	ICGC	ARRILAGLG	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.1667
p.S461F	TCGA-FS-A1YY	SKCM	TCGA	FSGGWRMRV	DEG_MDM2_SWIB_1	452:460	Mutation rewiring degron network	0.3056
p.S461F	DO37415	SKCM	ICGC	FSGGWRMRV	DEG_MDM2_SWIB_1	452:460	Mutation rewiring degron network	0.3056
p.R459C	TCGA-HT-8564	LGG	TCGA	FSGGWRMRV	DEG_MDM2_SWIB_1	452:460	Mutation altering degron motif	0.719
p.R459C	DO44623	LGG	ICGC	FSGGWRMRV	DEG_MDM2_SWIB_1	452:460	Mutation altering degron motif	0.719
p.R457C	TCGA-QQ-A8VF	SARC	TCGA	FSGGWRMRV	DEG_MDM2_SWIB_1	452:460	Mutation altering degron motif	0.719
p.R457C	DO220258	SARC	ICGC	FSGGWRMRV	DEG_MDM2_SWIB_1	452:460	Mutation altering degron motif	0.719
p.A424V	DO222427	BTCA	ICGC	ARRILAGLG	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.1389
p.A421S	DO227906	COCA	ICGC	ARRILAGLG	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.0556
p.R433Q	DO233254	GACA	ICGC	ARRILAGLG	DEG_APCC_DBOX_1	431:439	Mutation altering degron motif	0.6218
p.K430N	DO233747	GACA	ICGC	ARRILAGLG	DEG_APCC_DBOX_1	431:439	Mutation blocking ubiquitination signal	0.75
p.G454R	SIDM00789	Colorectal Carcinoma	GDSC	FSGGWRMRV	DEG_MDM2_SWIB_1	452:460	Mutation altering degron motif	0.6457
p.G454R	ACH-000997	Colon/Colorectal Cancer	CCLE	FSGGWRMRV	DEG_MDM2_SWIB_1	452:460	Mutation altering degron motif	0.6457
p.G454R	HCT-15	large intestine	COSMIC	FSGGWRMRV	DEG_MDM2_SWIB_1	452:460	Mutation altering degron motif	0.6457
p.R457H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	FSGGWRMRV	DEG_MDM2_SWIB_1	452:460	Mutation altering degron motif	0.7133
p.R457H	PF-382	haematopoietic and lymphoid tissue	COSMIC	FSGGWRMRV	DEG_MDM2_SWIB_1	452:460	Mutation altering degron motif	0.7133
p.G455D	SIDM01729	Endometrial Carcinoma	GDSC	FSGGWRMRV	DEG_MDM2_SWIB_1	452:460	Mutation altering degron motif	0.6087
p.G455D	ACH-000909	Endometrial/Uterine Cancer	CCLE	FSGGWRMRV	DEG_MDM2_SWIB_1	452:460	Mutation altering degron motif	0.6087
p.R433W	SIDM01619	Endometrial Carcinoma	GDSC	ARRILAGLG	DEG_APCC_DBOX_1	431:439	Mutation altering degron motif	0.7523
p.R433W	ACH-000984	Endometrial/Uterine Cancer	CCLE	ARRILAGLG	DEG_APCC_DBOX_1	431:439	Mutation altering degron motif	0.7523
p.R460Q	CW-2	large intestine	COSMIC	FSGGWRMRV	DEG_MDM2_SWIB_1	452:460	Mutation altering degron motif	0.7329
p.D445N	COLO-792	skin	COSMIC	ARRILAGLG	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.1667
p.D445N	COLO-792	skin	COSMIC	FSGGWRMRV	DEG_MDM2_SWIB_1	452:460	Mutation rewiring degron network	0.1389

Kaplan plot for ABCF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABCF1

UniProt ID: Q8NE71

Entrez ID: 23

Protein name: ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ABCF1 in