DegronMD

Uniprot ID: Q8NE71

Source protein: ATP-binding cassette sub-family F member 1

Source gene: ABCF1

Class: DEG_MDM2_SWIB_1

Location: 452:460

E3 ligase: MDM2

DEGRON score: 0.7667

ASA_SCORE: 31.9556

COIL: 0.3033

CONS_SCORE: 0.7678

DSS_SCORE: 0.284

HELIX: 0.6878

FCONS_SCORE: 1.4105

RIG_SCORE: 0.7692

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S461F	TCGA-FS-A1YY	SKCM	TCGA	FSGGWRMRV	DEG_MDM2_SWIB_1	0.3056
p.S461F	DO37415	SKCM	ICGC	FSGGWRMRV	DEG_MDM2_SWIB_1	0.3056
p.R459C	TCGA-HT-8564	LGG	TCGA	FSGGWRMRV	DEG_MDM2_SWIB_1	0.719
p.R459C	DO44623	LGG	ICGC	FSGGWRMRV	DEG_MDM2_SWIB_1	0.719
p.R457C	TCGA-QQ-A8VF	SARC	TCGA	FSGGWRMRV	DEG_MDM2_SWIB_1	0.719
p.R457C	DO220258	SARC	ICGC	FSGGWRMRV	DEG_MDM2_SWIB_1	0.719
p.G454R	SIDM00789	Colorectal Carcinoma	GDSC	FSGGWRMRV	DEG_MDM2_SWIB_1	0.6457
p.G454R	ACH-000997	Colon/Colorectal Cancer	CCLE	FSGGWRMRV	DEG_MDM2_SWIB_1	0.6457
p.G454R	HCT-15	large_intestine	COSMIC	FSGGWRMRV	DEG_MDM2_SWIB_1	0.6457
p.R457H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	FSGGWRMRV	DEG_MDM2_SWIB_1	0.7133
p.R457H	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	FSGGWRMRV	DEG_MDM2_SWIB_1	0.7133
p.G455D	SIDM01729	Endometrial Carcinoma	GDSC	FSGGWRMRV	DEG_MDM2_SWIB_1	0.6087
p.G455D	ACH-000909	Endometrial/Uterine Cancer	CCLE	FSGGWRMRV	DEG_MDM2_SWIB_1	0.6087
p.R460Q	CW-2	large_intestine	COSMIC	FSGGWRMRV	DEG_MDM2_SWIB_1	0.7329
p.D445N	COLO-792	skin	COSMIC	FSGGWRMRV	DEG_MDM2_SWIB_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NE71	ATP-binding cassette sub-family F member 1	DEG_MDM2_SWIB_1	452:460	FSGGWRMRV	MDM2	0.7667	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons