DegronMD

Uniprot ID: P49790

Source protein: Nuclear pore complex protein Nup153

Source gene: NUP153

Class: DEG_APCC_DBOX_1

Location: 308:316

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9676

ASA_SCORE: 81.7556

COIL: 0.359

CONS_SCORE: 0.5847

DSS_SCORE: 0.4285

HELIX: 0.5866

FCONS_SCORE: 1.0331

RIG_SCORE: 0.7776

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R310Q	TCGA-19-1787	GBM	TCGA	ARRILQSLE	DEG_APCC_DBOX_1	0.6218
p.R310Q	DO13522	GBM	ICGC	ARRILQSLE	DEG_APCC_DBOX_1	0.6218
p.G302S	TCGA-AP-A0LM	UCEC	TCGA	ARRILQSLE	DEG_APCC_DBOX_1	0.1667
p.G302S	DO43306	UCEC	ICGC	ARRILQSLE	DEG_APCC_DBOX_1	0.1667
p.I311L	TCGA-B5-A3FC	UCEC	TCGA	ARRILQSLE	DEG_APCC_DBOX_1	0.6063
p.I311L	DO41871	UCEC	ICGC	ARRILQSLE	DEG_APCC_DBOX_1	0.6063
p.E316Q	TCGA-JW-A5VL	CESC	TCGA	ARRILQSLE	DEG_APCC_DBOX_1	0.5633
p.E316Q	DO49976	CESC	ICGC	ARRILQSLE	DEG_APCC_DBOX_1	0.5633
p.S300Y	DO229036	LICA	ICGC	ARRILQSLE	DEG_APCC_DBOX_1	0.1111
p.K317R	SIDM02063	Colorectal Carcinoma	GDSC	ARRILQSLE	DEG_APCC_DBOX_1	0.75
p.A323V	SIDM00789	Colorectal Carcinoma	GDSC	ARRILQSLE	DEG_APCC_DBOX_1	0.1389
p.A323V	HCT-15	large_intestine	COSMIC	ARRILQSLE	DEG_APCC_DBOX_1	0.1389
p.K317N	SIDM00193	Colorectal Carcinoma	GDSC	ARRILQSLE	DEG_APCC_DBOX_1	0.75
p.K317N	ACH-000991	Colon/Colorectal Cancer	CCLE	ARRILQSLE	DEG_APCC_DBOX_1	0.75
p.K317N	SNU-81	large_intestine	COSMIC	ARRILQSLE	DEG_APCC_DBOX_1	0.75
p.M318I	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	ARRILQSLE	DEG_APCC_DBOX_1	0.2778
p.M318I	ACH-000980	Lung Cancer	CCLE	ARRILQSLE	DEG_APCC_DBOX_1	0.2778
p.M318I	NCI-H1155	lung	COSMIC	ARRILQSLE	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49790	Nuclear pore complex protein Nup153	DEG_APCC_DBOX_1	308:316	ARRILQSLE	APC,CDC20,FZR1	0.9676	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons