DegronMD

Uniprot ID: O60500

Source protein: Nephrin

Source gene: NPHS1

Class: DEG_APCC_DBOX_1

Location: 826:834

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6594

ASA_SCORE: 56.8444

COIL: 0.1162

CONS_SCORE: 0.4405

DSS_SCORE: 0.1962

HELIX: 0.0059

FCONS_SCORE: 0.8641

RIG_SCORE: 0.883

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R831G	TCGA-90-7769	LUSC	TCGA	ARRLLRLVV	DEG_APCC_DBOX_1	0.6457
p.R831G	DO26822	LUSC	ICGC	ARRLLRLVV	DEG_APCC_DBOX_1	0.6457
p.A823V	TCGA-AA-A01R	COAD	TCGA	ARRLLRLVV	DEG_APCC_DBOX_1	0.25
p.A823V	DO7934	COAD	ICGC	ARRLLRLVV	DEG_APCC_DBOX_1	0.25
p.A823V	DO233044	GACA	ICGC	ARRLLRLVV	DEG_APCC_DBOX_1	0.25
p.Q839K	TCGA-BF-A1Q0	SKCM	TCGA	ARRLLRLVV	DEG_APCC_DBOX_1	0.1944
p.Q839K	DO47374	SKCM	ICGC	ARRLLRLVV	DEG_APCC_DBOX_1	0.1944
p.R827Q	TCGA-EE-A29D	SKCM	TCGA	ARRLLRLVV	DEG_APCC_DBOX_1	0.7329
p.R827Q	DO38123	SKCM	ICGC	ARRLLRLVV	DEG_APCC_DBOX_1	0.7329
p.V818A	TCGA-MA-AA42	CESC	TCGA	ARRLLRLVV	DEG_APCC_DBOX_1	0.1111
p.V818A	DO219724	CESC	ICGC	ARRLLRLVV	DEG_APCC_DBOX_1	0.1111
p.L830I	DO229009	LICA	ICGC	ARRLLRLVV	DEG_APCC_DBOX_1	0.7174
p.I817N	DO222420	MELA	ICGC	ARRLLRLVV	DEG_APCC_DBOX_1	0.0833
p.P824H	DO228640	PRAD	ICGC	ARRLLRLVV	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60500	Nephrin	DEG_APCC_DBOX_1	826:834	ARRLLRLVV	APC,CDC20,FZR1	0.6594	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons