DegronMD - O60500(NPHS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G601V	TCGA-17-Z005	LUAD	TCGA	ARSVLLQVS	DEG_APCC_DBOX_1	605:613	Mutation rewiring degron network	0.2222
p.G601S	TCGA-63-A5MH	LUSC	TCGA	ARSVLLQVS	DEG_APCC_DBOX_1	605:613	Mutation rewiring degron network	0.2222
p.G601S	DO219146	LUSC	ICGC	ARSVLLQVS	DEG_APCC_DBOX_1	605:613	Mutation rewiring degron network	0.2222
p.R831G	TCGA-90-7769	LUSC	TCGA	ARRLLRLVV	DEG_APCC_DBOX_1	826:834	Mutation altering degron motif	0.6457
p.R831G	DO26822	LUSC	ICGC	ARRLLRLVV	DEG_APCC_DBOX_1	826:834	Mutation altering degron motif	0.6457
p.K504I	TCGA-A5-A2K7	UCEC	TCGA	RRVHLGSVE	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.3056
p.K504I	DO41271	UCEC	ICGC	RRVHLGSVE	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.3056
p.A823V	TCGA-AA-A01R	COAD	TCGA	ARRLLRLVV	DEG_APCC_DBOX_1	826:834	Mutation rewiring degron network	0.25
p.A823V	DO7934	COAD	ICGC	ARRLLRLVV	DEG_APCC_DBOX_1	826:834	Mutation rewiring degron network	0.25
p.A823V	DO233044	GACA	ICGC	ARRLLRLVV	DEG_APCC_DBOX_1	826:834	Mutation rewiring degron network	0.25
p.S613P	TCGA-AX-A06F	UCEC	TCGA	ARSVLLQVS	DEG_APCC_DBOX_1	605:613	Mutation altering degron motif	0.5641
p.S613P	DO41752	UCEC	ICGC	ARSVLLQVS	DEG_APCC_DBOX_1	605:613	Mutation altering degron motif	0.5641
p.Q839K	TCGA-BF-A1Q0	SKCM	TCGA	ARRLLRLVV	DEG_APCC_DBOX_1	826:834	Mutation rewiring degron network	0.1944
p.Q839K	DO47374	SKCM	ICGC	ARRLLRLVV	DEG_APCC_DBOX_1	826:834	Mutation rewiring degron network	0.1944
p.F509L	TCGA-BS-A0UV	UCEC	TCGA	RRVHLGSVE	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.1667
p.F509L	DO42793	UCEC	ICGC	RRVHLGSVE	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.1667
p.R827Q	TCGA-EE-A29D	SKCM	TCGA	ARRLLRLVV	DEG_APCC_DBOX_1	826:834	Mutation altering degron motif	0.7329
p.R827Q	DO38123	SKCM	ICGC	ARRLLRLVV	DEG_APCC_DBOX_1	826:834	Mutation altering degron motif	0.7329
p.V818A	TCGA-MA-AA42	CESC	TCGA	ARRLLRLVV	DEG_APCC_DBOX_1	826:834	Mutation rewiring degron network	0.1111
p.V818A	DO219724	CESC	ICGC	ARRLLRLVV	DEG_APCC_DBOX_1	826:834	Mutation rewiring degron network	0.1111
p.E503D	DO222762	COCA	ICGC	RRVHLGSVE	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.5647
p.S494L	DO14171	HNSC	ICGC	RRVHLGSVE	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.3056
p.T486N	DO228952	LICA	ICGC	RRVHLGSVE	DEG_APCC_DBOX_1	495:503	Mutation rewiring degron network	0.0833
p.S614Y	DO228985	LICA	ICGC	ARSVLLQVS	DEG_APCC_DBOX_1	605:613	Mutation rewiring degron network	0.3056
p.T622N	DO229027	LICA	ICGC	ARSVLLQVS	DEG_APCC_DBOX_1	605:613	Mutation rewiring degron network	0.0833
p.L830I	DO229009	LICA	ICGC	ARRLLRLVV	DEG_APCC_DBOX_1	826:834	Mutation altering degron motif	0.7174
p.R496S	DO229008	LICA	ICGC	RRVHLGSVE	DEG_APCC_DBOX_1	495:503	Mutation altering degron motif	0.7427
p.R595P	DO231169	LUSC	ICGC	ARSVLLQVS	DEG_APCC_DBOX_1	605:613	Mutation rewiring degron network	0.0556
p.I817N	DO222420	MELA	ICGC	ARRLLRLVV	DEG_APCC_DBOX_1	826:834	Mutation rewiring degron network	0.0833
p.P824H	DO228640	PRAD	ICGC	ARRLLRLVV	DEG_APCC_DBOX_1	826:834	Mutation rewiring degron network	0.2778
p.H617R	SIDM02050	Colorectal Carcinoma	GDSC	ARSVLLQVS	DEG_APCC_DBOX_1	605:613	Mutation rewiring degron network	0.2222
p.A597D	SIDM00689	B-Lymphoblastic Leukemia	GDSC	ARSVLLQVS	DEG_APCC_DBOX_1	605:613	Mutation rewiring degron network	0.1111
p.A597D	SIDM00507	Other Solid Cancers	GDSC	ARSVLLQVS	DEG_APCC_DBOX_1	605:613	Mutation rewiring degron network	0.1111
p.A597D	SIDM00876	Non-Cancerous	GDSC	ARSVLLQVS	DEG_APCC_DBOX_1	605:613	Mutation rewiring degron network	0.1111
p.A597D	SIDM00877	Breast Carcinoma	GDSC	ARSVLLQVS	DEG_APCC_DBOX_1	605:613	Mutation rewiring degron network	0.1111
p.G601A	SIDM00466	Ovarian Carcinoma	GDSC	ARSVLLQVS	DEG_APCC_DBOX_1	605:613	Mutation rewiring degron network	0.2222
p.G601A	SIDM00526	Chronic Myelogenous Leukemia	GDSC	ARSVLLQVS	DEG_APCC_DBOX_1	605:613	Mutation rewiring degron network	0.2222
p.C623F	SIDM00476	Ovarian Carcinoma	GDSC	ARSVLLQVS	DEG_APCC_DBOX_1	605:613	Mutation rewiring degron network	0.0556
p.C623F	ACH-001373	Ovarian Cancer	CCLE	ARSVLLQVS	DEG_APCC_DBOX_1	605:613	Mutation rewiring degron network	0.0556
p.C623F	OV-17R	ovary	COSMIC	ARSVLLQVS	DEG_APCC_DBOX_1	605:613	Mutation rewiring degron network	0.0556
p.S607G	ACH-000276	Breast Cancer	CCLE	ARSVLLQVS	DEG_APCC_DBOX_1	605:613	Mutation altering degron motif	0.5882

Kaplan plot for NPHS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NPHS1

UniProt ID: O60500

Entrez ID: 4868

Protein name: Nephrin (Renal glomerulus-specific cell adhesion receptor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NPHS1 in