DegronMD

Uniprot ID: O60500

Source protein: Nephrin

Source gene: NPHS1

Class: DEG_APCC_DBOX_1

Location: 605:613

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6317

ASA_SCORE: 54.0111

COIL: 0.2294

CONS_SCORE: 0.4267

DSS_SCORE: 0.4347

HELIX: 0.0093

FCONS_SCORE: 0.9512

RIG_SCORE: 0.7394

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G601V	TCGA-17-Z005	LUAD	TCGA	ARSVLLQVS	DEG_APCC_DBOX_1	0.2222
p.G601S	TCGA-63-A5MH	LUSC	TCGA	ARSVLLQVS	DEG_APCC_DBOX_1	0.2222
p.G601S	DO219146	LUSC	ICGC	ARSVLLQVS	DEG_APCC_DBOX_1	0.2222
p.S613P	TCGA-AX-A06F	UCEC	TCGA	ARSVLLQVS	DEG_APCC_DBOX_1	0.5641
p.S613P	DO41752	UCEC	ICGC	ARSVLLQVS	DEG_APCC_DBOX_1	0.5641
p.S614Y	DO228985	LICA	ICGC	ARSVLLQVS	DEG_APCC_DBOX_1	0.3056
p.T622N	DO229027	LICA	ICGC	ARSVLLQVS	DEG_APCC_DBOX_1	0.0833
p.R595P	DO231169	LUSC	ICGC	ARSVLLQVS	DEG_APCC_DBOX_1	0.0556
p.H617R	SIDM02050	Colorectal Carcinoma	GDSC	ARSVLLQVS	DEG_APCC_DBOX_1	0.2222
p.A597D	SIDM00689	B-Lymphoblastic Leukemia	GDSC	ARSVLLQVS	DEG_APCC_DBOX_1	0.1111
p.A597D	SIDM00507	Other Solid Cancers	GDSC	ARSVLLQVS	DEG_APCC_DBOX_1	0.1111
p.A597D	SIDM00876	Non-Cancerous	GDSC	ARSVLLQVS	DEG_APCC_DBOX_1	0.1111
p.A597D	SIDM00877	Breast Carcinoma	GDSC	ARSVLLQVS	DEG_APCC_DBOX_1	0.1111
p.G601A	SIDM00466	Ovarian Carcinoma	GDSC	ARSVLLQVS	DEG_APCC_DBOX_1	0.2222
p.G601A	SIDM00526	Chronic Myelogenous Leukemia	GDSC	ARSVLLQVS	DEG_APCC_DBOX_1	0.2222
p.C623F	SIDM00476	Ovarian Carcinoma	GDSC	ARSVLLQVS	DEG_APCC_DBOX_1	0.0556
p.C623F	ACH-001373	Ovarian Cancer	CCLE	ARSVLLQVS	DEG_APCC_DBOX_1	0.0556
p.C623F	OV-17R	ovary	COSMIC	ARSVLLQVS	DEG_APCC_DBOX_1	0.0556
p.S607G	ACH-000276	Breast Cancer	CCLE	ARSVLLQVS	DEG_APCC_DBOX_1	0.5882

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60500	Nephrin	DEG_APCC_DBOX_1	605:613	ARSVLLQVS	APC,CDC20,FZR1	0.6317	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons