DegronMD

Uniprot ID: O60500

Source protein: Nephrin

Source gene: NPHS1

Class: DEG_APCC_DBOX_1

Location: 495:503

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.643

ASA_SCORE: 59.6556

COIL: 0.2297

CONS_SCORE: 0.321

DSS_SCORE: 0.4975

HELIX: 0.027

FCONS_SCORE: 0.8023

RIG_SCORE: 0.7031

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K504I	TCGA-A5-A2K7	UCEC	TCGA	RRVHLGSVE	DEG_APCC_DBOX_1	0.3056
p.K504I	DO41271	UCEC	ICGC	RRVHLGSVE	DEG_APCC_DBOX_1	0.3056
p.F509L	TCGA-BS-A0UV	UCEC	TCGA	RRVHLGSVE	DEG_APCC_DBOX_1	0.1667
p.F509L	DO42793	UCEC	ICGC	RRVHLGSVE	DEG_APCC_DBOX_1	0.1667
p.E503D	DO222762	COCA	ICGC	RRVHLGSVE	DEG_APCC_DBOX_1	0.5647
p.S494L	DO14171	HNSC	ICGC	RRVHLGSVE	DEG_APCC_DBOX_1	0.3056
p.T486N	DO228952	LICA	ICGC	RRVHLGSVE	DEG_APCC_DBOX_1	0.0833
p.R496S	DO229008	LICA	ICGC	RRVHLGSVE	DEG_APCC_DBOX_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60500	Nephrin	DEG_APCC_DBOX_1	495:503	RRVHLGSVE	APC,CDC20,FZR1	0.643	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons