DegronMD

Uniprot ID: Q96M86

Source protein: Dynein heavy chain domain-containing protein 1

Source gene: DNHD1

Class: DEG_APCC_DBOX_1

Location: 4477:4485

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.564

ASA_SCORE: 34.9667

COIL: 0.3606

CONS_SCORE: 0.5108

DSS_SCORE: 0.3379

HELIX: 0.6266

FCONS_SCORE: 1.3

RIG_SCORE: 0.7408

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A4489V	TCGA-06-5416	GBM	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	0.2222
p.A4489V	DO10880	GBM	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	0.2222
p.E4488K	TCGA-86-A4JF	LUAD	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	0.25
p.E4488K	DO45317	LUAD	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	0.25
p.R4478W	TCGA-A5-A1OF	UCEC	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	0.8634
p.R4478W	TCGA-AP-A051	UCEC	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	0.8634
p.R4478W	DO42568	UCEC	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	0.8634
p.R4478W	DO42673	UCEC	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	0.8634
p.R4478Q	TCGA-AA-3947	COAD	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	0.7329
p.R4478Q	TCGA-HC-8257	PRAD	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	0.7329
p.R4478Q	DO8192	COAD	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	0.7329
p.R4478Q	DO49814	PRAD	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	0.7329
p.R4479Q	TCGA-AR-A1AU	BRCA	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	0.6218
p.R4479Q	DO5193	BRCA	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	0.6218
p.R4479Q	DO233882	GACA	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	0.6218
p.G4483S	TCGA-D3-A8GI	SKCM	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	0.5882
p.G4483S	DO50284	SKCM	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	0.5882
p.G4483D	TCGA-D3-A8GI	SKCM	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	0.6087
p.G4483D	DO50284	SKCM	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	0.6087
p.D4467N	TCGA-FI-A2D5	UCEC	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	0.0556
p.D4467N	DO41331	UCEC	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	0.0556
p.A4477T	DO227984	COCA	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	0.6028
p.E4488D	SIDM00945	Colorectal Carcinoma	GDSC	ARRPLEGVL	DEG_APCC_DBOX_1	0.25
p.E4488D	ACH-000895	Colon/Colorectal Cancer	CCLE	ARRPLEGVL	DEG_APCC_DBOX_1	0.25
p.E4488D	CL-34	large_intestine	COSMIC	ARRPLEGVL	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96M86	Dynein heavy chain domain-containing protein 1	DEG_APCC_DBOX_1	4477:4485	ARRPLEGVL	APC,CDC20,FZR1	0.564	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons