DegronMD - Q96M86(DNHD1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A4489V	TCGA-06-5416	GBM	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation rewiring degron network	0.2222
p.A4489V	DO10880	GBM	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation rewiring degron network	0.2222
p.E4488K	TCGA-86-A4JF	LUAD	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation rewiring degron network	0.25
p.E4488K	DO45317	LUAD	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation rewiring degron network	0.25
p.R4478W	TCGA-A5-A1OF	UCEC	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation altering degron motif	0.8634
p.R4478W	TCGA-AP-A051	UCEC	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation altering degron motif	0.8634
p.R4478W	DO42568	UCEC	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation altering degron motif	0.8634
p.R4478W	DO42673	UCEC	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation altering degron motif	0.8634
p.R4478Q	TCGA-AA-3947	COAD	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation altering degron motif	0.7329
p.R4478Q	TCGA-HC-8257	PRAD	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation altering degron motif	0.7329
p.R4478Q	DO8192	COAD	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation altering degron motif	0.7329
p.R4478Q	DO49814	PRAD	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation altering degron motif	0.7329
p.S1450C	TCGA-AC-A23H	BRCA	TCGA	LPLHPD	LIG_APCC_ABBA_1	1438:1443	Mutation rewiring degron network	0.1389
p.S1450C	DO2401	BRCA	ICGC	LPLHPD	LIG_APCC_ABBA_1	1438:1443	Mutation rewiring degron network	0.1389
p.R4479Q	TCGA-AR-A1AU	BRCA	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation altering degron motif	0.6218
p.R4479Q	DO5193	BRCA	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation altering degron motif	0.6218
p.R4479Q	DO233882	GACA	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation altering degron motif	0.6218
p.K1446M	TCGA-D1-A16X	UCEC	TCGA	LPLHPD	LIG_APCC_ABBA_1	1438:1443	Mutation substituting flanking lysine	0.3611
p.K1446M	DO41799	UCEC	ICGC	LPLHPD	LIG_APCC_ABBA_1	1438:1443	Mutation substituting flanking lysine	0.3611
p.G4483S	TCGA-D3-A8GI	SKCM	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation altering degron motif	0.5882
p.G4483S	DO50284	SKCM	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation altering degron motif	0.5882
p.G4483D	TCGA-D3-A8GI	SKCM	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation altering degron motif	0.6087
p.G4483D	DO50284	SKCM	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation altering degron motif	0.6087
p.D4467N	TCGA-FI-A2D5	UCEC	TCGA	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation rewiring degron network	0.0556
p.D4467N	DO41331	UCEC	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation rewiring degron network	0.0556
p.A4477T	DO227984	COCA	ICGC	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation altering degron motif	0.6028
p.T4292I	DO45171	LIRI	ICGC	LQAHRGR	SCF_FBXL2	4281:4287	Mutation rewiring degron network	0.1944
p.Q4295H	DO51499	PACA	ICGC	LQAHRGR	SCF_FBXL2	4281:4287	Mutation rewiring degron network	0.1111
p.E4488D	SIDM00945	Colorectal Carcinoma	GDSC	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation rewiring degron network	0.25
p.E4488D	ACH-000895	Colon/Colorectal Cancer	CCLE	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation rewiring degron network	0.25
p.E4488D	CL-34	large intestine	COSMIC	ARRPLEGVL	DEG_APCC_DBOX_1	4477:4485	Mutation rewiring degron network	0.25
p.R4274W	SIDM01086	B-Lymphoblastic Leukemia	GDSC	LQAHRGR	SCF_FBXL2	4281:4287	Mutation rewiring degron network	0.1389
p.R4274W	ACH-000874	Leukemia	CCLE	LQAHRGR	SCF_FBXL2	4281:4287	Mutation rewiring degron network	0.1389
p.R4274W	RS4-11	haematopoietic and lymphoid tissue	COSMIC	LQAHRGR	SCF_FBXL2	4281:4287	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNHD1

UniProt ID: Q96M86

Entrez ID: 144132

Protein name: Dynein heavy chain domain-containing protein 1 (Dynein heavy chain domain 1-like protein) (Protein CCDC35)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for DNHD1 in