DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
LQAHRGR
Uniprot ID:
Q96M86
Source protein:
Dynein heavy chain domain-containing protein 1
Source gene:
DNHD1
Class:
SCF_FBXL2
Location:
4281:4287
E3 ligase:
FBXL2
DEGRON score:
0.7249
ASA_SCORE:
75.3429
COIL:
0.7209
CONS_SCORE:
0.6189
DSS_SCORE:
0.1539
HELIX:
0.1216
FCONS_SCORE:
1.4514
RIG_SCORE:
0.7737
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T4292I
DO45171
LIRI
ICGC
LQAHRGR
SCF_FBXL2
0.1944
p.Q4295H
DO51499
PACA
ICGC
LQAHRGR
SCF_FBXL2
0.1111
p.R4274W
SIDM01086
B-Lymphoblastic Leukemia
GDSC
LQAHRGR
SCF_FBXL2
0.1389
p.R4274W
ACH-000874
Leukemia
CCLE
LQAHRGR
SCF_FBXL2
0.1389
p.R4274W
RS4-11
haematopoietic_and_lymphoid_tissue
COSMIC
LQAHRGR
SCF_FBXL2
0.1389
Drug responses associated with DNHD1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LQAHRGR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96M86
Dynein heavy chain domain-containing protein 1
SCF_FBXL2
4281:4287
LQAHRGR
FBXL2
0.7249
More...
