DegronMD

Uniprot ID: Q96M86

Source protein: Dynein heavy chain domain-containing protein 1

Source gene: DNHD1

Class: LIG_APCC_ABBA_1

Location: 1438:1443

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7855

ASA_SCORE: 79.5667

COIL: 0.8925

CONS_SCORE: 0.3492

DSS_SCORE: 0.2151

HELIX: 0.0277

FCONS_SCORE: 0.6565

RIG_SCORE: 0.7587

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1450C	TCGA-AC-A23H	BRCA	TCGA	LPLHPD	LIG_APCC_ABBA_1	0.1389
p.S1450C	DO2401	BRCA	ICGC	LPLHPD	LIG_APCC_ABBA_1	0.1389
p.K1446M	TCGA-D1-A16X	UCEC	TCGA	LPLHPD	LIG_APCC_ABBA_1	0.3611
p.K1446M	DO41799	UCEC	ICGC	LPLHPD	LIG_APCC_ABBA_1	0.3611

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96M86	Dynein heavy chain domain-containing protein 1	LIG_APCC_ABBA_1	1438:1443	LPLHPD	APC,CDC20,FZR1	0.7855	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons