DegronMD

Uniprot ID: P49796

Source protein: Regulator of G-protein signaling 3

Source gene: RGS3

Class: DEG_APCC_DBOX_1

Location: 272:280

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9488

ASA_SCORE: 134.9556

COIL: 0.8869

CONS_SCORE: 0.3334

DSS_SCORE: 0.4101

HELIX: 0.0472

FCONS_SCORE: 1.7384

RIG_SCORE: 0.7969

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M286I	TCGA-63-A5MW	LUSC	TCGA	ARRRLRPLR	DEG_APCC_DBOX_1	0.1667
p.R274W	TCGA-AA-3864	COAD	TCGA	ARRRLRPLR	DEG_APCC_DBOX_1	0.7523
p.P282Q	TCGA-BF-A1Q0	SKCM	TCGA	ARRRLRPLR	DEG_APCC_DBOX_1	0.2778
p.G290W	TCGA-EE-A2GH	SKCM	TCGA	ARRRLRPLR	DEG_APCC_DBOX_1	0.0556
p.P282S	TCGA-EE-A3AC	SKCM	TCGA	ARRRLRPLR	DEG_APCC_DBOX_1	0.2778
p.R275Q	TCGA-F5-6814	READ	TCGA	ARRRLRPLR	DEG_APCC_DBOX_1	0.6218
p.G288E	TCGA-W3-AA1V	SKCM	TCGA	ARRRLRPLR	DEG_APCC_DBOX_1	0.1111
p.R279H	DO230323	COCA	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	0.8244
p.R279H	DO41644	UCEC	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	0.8244
p.P273H	DO22333	LGG	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	0.7694
p.M263I	DO228508	LICA	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	0.0833
p.A279S	DO229026	LICA	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	0.7588
p.C285F	DO229037	LICA	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	0.1944
p.P265S	DO37567	SKCM	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	0.1389
p.Q266K	DO37896	SKCM	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	0.1667
p.G274R	DO38795	STAD	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	0.7568
p.R270W	DO43891	UCEC	ICGC	ARRRLRPLR	DEG_APCC_DBOX_1	0.2778
p.G289S	SIDM01763	Rhabdomyosarcoma	GDSC	ARRRLRPLR	DEG_APCC_DBOX_1	0.0833
p.V269I	NB13	autonomic_ganglia	COSMIC	ARRRLRPLR	DEG_APCC_DBOX_1	0.25
p.V269I	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	ARRRLRPLR	DEG_APCC_DBOX_1	0.25
p.R270L	OV-90	ovary	COSMIC	ARRRLRPLR	DEG_APCC_DBOX_1	0.2778
p.P275L	Hs939-T	skin	COSMIC	ARRRLRPLR	DEG_APCC_DBOX_1	0.7582
p.V275A	GP5d	large_intestine	COSMIC	ARRRLRPLR	DEG_APCC_DBOX_1	0.6936
p.R262H	SiHa	cervix	COSMIC	ARRRLRPLR	DEG_APCC_DBOX_1	0.0556
p.T269M	HCT-15	large_intestine	COSMIC	ARRRLRPLR	DEG_APCC_DBOX_1	0.25
p.G282W	RKO	large_intestine	COSMIC	ARRRLRPLR	DEG_APCC_DBOX_1	0.2778
p.V283M	MZ7-mel	skin	COSMIC	ARRRLRPLR	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49796	Regulator of G-protein signaling 3	DEG_APCC_DBOX_1	272:280	ARRRLRPLR	APC,CDC20,FZR1	0.9488	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARRRLRPLR

Degron related mutations and impact score

Drug responses associated with RGS3 mutations

All proteins holding degron of ARRRLRPLR