DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ARRSLPPIV
Uniprot ID:
A6NGB0
Source protein:
Transmembrane protein 191C
Source gene:
TMEM191C
Class:
DEG_APCC_DBOX_1
Location:
18:26
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9776
ASA_SCORE:
89.2889
COIL:
0.9168
CONS_SCORE:
0.7749
DSS_SCORE:
0.4415
HELIX:
0.0158
FCONS_SCORE:
0.9467
RIG_SCORE:
0.7256
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with TMEM191C mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ARRSLPPIV
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NGB0
Transmembrane protein 191C
DEG_APCC_DBOX_1
18:26
ARRSLPPIV
APC,CDC20,FZR1
0.9776
More...
P0C7N4
Transmembrane protein 191B
DEG_APCC_DBOX_1
18:26
ARRSLPPIV
APC,CDC20,FZR1
0.9991
More...