DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
ARRSLPPIV
Uniprot ID:
P0C7N4
Source protein:
Transmembrane protein 191B
Source gene:
TMEM191B
Class:
DEG_APCC_DBOX_1
Location:
18:26
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9991
ASA_SCORE:
79.6778
COIL:
0.8739
CONS_SCORE:
0
DSS_SCORE:
0.4415
HELIX:
0.0151
FCONS_SCORE:
0
RIG_SCORE:
0.7256
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with TMEM191B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ARRSLPPIV
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NGB0
Transmembrane protein 191C
DEG_APCC_DBOX_1
18:26
ARRSLPPIV
APC,CDC20,FZR1
0.9776
More...
P0C7N4
Transmembrane protein 191B
DEG_APCC_DBOX_1
18:26
ARRSLPPIV
APC,CDC20,FZR1
0.9991
More...