DegronMD

Uniprot ID: Q13895

Source protein: Bystin

Source gene: BYSL

Class: DEG_APCC_DBOX_1

Location: 143:151

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8855

ASA_SCORE: 68.2889

COIL: 0.3729

CONS_SCORE: 0.4975

DSS_SCORE: 0.4561

HELIX: 0.6017

FCONS_SCORE: 1.1787

RIG_SCORE: 0.8154

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A143V	TCGA-D3-A3MR	SKCM	TCGA	ARRTLADII	DEG_APCC_DBOX_1	0.5825
p.A143V	DO47256	SKCM	ICGC	ARRTLADII	DEG_APCC_DBOX_1	0.5825
p.R145H	TCGA-EI-6917	READ	TCGA	ARRTLADII	DEG_APCC_DBOX_1	0.7133
p.R145H	DO36881	READ	ICGC	ARRTLADII	DEG_APCC_DBOX_1	0.7133
p.P142S	DO222702	MELA	ICGC	ARRTLADII	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13895	Bystin	DEG_APCC_DBOX_1	143:151	ARRTLADII	APC,CDC20,FZR1	0.8855	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons